MATERNAL HYPERINSULINEMIA AND FETAL PROGRAMMING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在过去的三十年里，超重/肥胖的个人(儿童、青少年和成年人)的数量在美国达到了流行病的比例。有几个因素被认为在肥胖症流行的病因中起到了作用。人们认识到，生命早期营养经历的改变会影响代谢系统的发展(代谢编程效应)，从而导致成人发病的代谢性疾病。本研究旨在探讨出生后早期营养干预对大鼠下丘脑黑素皮质素系统发育的影响。这些研究使用了Patel博士开发的大鼠模型，在该模型中，小鼠要么以高脂肪(HF)饮食(类似于母乳)喂养，要么以高碳水化合物(HC)饮食喂养。以HC饮食饲养的后代成年后会过度吞噬和肥胖。这些研究使用各种神经解剖学技术来调查对下丘脑黑素皮质素系统的即时和长期影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Over the period of the past three decades, the number of overweight/obese individuals (children, adolescents and adults) has reached epidemic proportions in the United States. Several factors are recognized to play a role in the etiology of the obesity epidemic. Altered nutritional experiences during early periods of life are recognized to impact on the development of metabolic systems (metabolic programming effects) resulting in predisposition to adult-onset metabolic diseases. The purpose of this study is to investigate the effects of early postnatal nutritional manipulation on the development of the hypothalamic melanocortin system in the rat. These studies use a rat model developed by Dr. Patel whereby rat pups are either raised on a high fat (HF) diet (similar to maternal milk) or a high carbohydrate (HC) diet. Offspring raised on a HC diet are hyperphagic and obese as adults. These studies use a variety of neuroanatomical techniques to investigate the immediate and long-term impact on the hypothalamic melanocortin system.