MATERNAL HYPERINSULINEMIA AND FETAL PROGRAMMING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的三十年里，超重/肥胖的个人(儿童、青少年和成年人)的数量在美国达到了流行病的比例。有几个因素被认为在肥胖症流行的病因中起到了作用。人们认识到，生命早期营养经历的改变会影响代谢系统的发展(代谢编程效应)，从而导致成人发病的代谢性疾病。本研究旨在探讨出生后早期营养干预对大鼠下丘脑黑素皮质素系统发育的影响。这些研究使用了Patel博士开发的大鼠模型，在该模型中，小鼠要么以高脂肪(HF)饮食(类似于母乳)喂养，要么以高碳水化合物(HC)饮食喂养。以HC饮食饲养的后代成年后会过度吞噬和肥胖。这些研究将使用各种神经解剖学技术来调查对下丘脑黑素皮质素系统的即时和长期影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the period of the past three decades, the number of overweight/obese individuals (children, adolescents and adults) has reached epidemic proportions in the United States. Several factors are recognized to play a role in the etiology of the obesity epidemic. Altered nutritional experiences during early periods of life are recognized to impact on the development of metabolic systems (metabolic programming effects) resulting in predisposition to adult-onset metabolic diseases. The purpose of this study is to investigate the effects of early postnatal nutritional manipulation on the development of the hypothalamic melanocortin system in the rat. These studies use a rat model developed by Dr. Patel whereby rat pups are either raised on a high fat (HF) diet (similar to maternal milk) or a high carbohydrate (HC) diet. Offspring raised on a HC diet are hyperphagic and obese as adults. These studies will use a variety of neuroanatomical techniques to investigate the immediate and long-term impact on the hypothalamic melanocortin system.