Core 2: Brain mapping (267-289)

核心 2：大脑图谱 (267-289)

• 批准号: 8078167
• 负责人: Marie T Banich
• 金额: $ 40.56万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-03 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078167
• 关键词: Address; Archives; Area; Brain Mapping; Brain region; Clinical; Data; Data Analyses; Data Collection; Development; Diagnosis; Documentation; Electrophysiology (science); Functional Magnetic Resonance Imaging; Functional disorder; Goals; Link; Magnetic Resonance Imaging; Mental Health; Mental disorders; Methods; Morphologic artifacts; Neurobiology; Noise; Participant; Predisposition; Preparation; Procedures; Process; Quality Control; Research Methodology; Running; Seeds; Signal Transduction; Site; Source; Standardization; Statistical Methods; Structure; System; Techniques; Training; Treatment Efficacy; Work; data acquisition; data integration; data sharing; density; design; executive function; neuroimaging; psychologic; relating to nervous system; research study; tool

The main goal of this core is to provide the brain mapping expertise, both with regards to magnetic resonance imaging and electrophysiological techniques, for use in Projects 1,2,3, and 5. This core will enable examination at both the neurobiological and psychological levels of analysis, explicitly addressing a center goal of linking levels of analysis in our understanding of executive function. The core will provide for: a)the quality control, storage, analysis and archiving of MRI and ERP data; b) documentation of data structures and processing procedures c) the incorporating of new analytic tools into the data analysis path d) support staff for running brain mapping experiments e) training in these research methods as well as the creation of materials for training purposes f) preparation of data for data sharing, and other associated functions With regards to neuroimaging, this core will also provide: a) installation of system upgrades and improvements to hardware b) the development of new acquisition and pre-processing methods, especially those that deal with susceptibility artifact and low signal-to-noise ratio. c) the application of new statistical methods to data analysis d) clinical expertise should any structural abnormalities be observed in participants With regards to electrophysiological techniques, this core will also provide: a) standardization of data collection across high-density array recording system b) expand methods and approaches for the integration of data from fMRI and ERP experiments that have been designed in parallel. More specifically it will examine various ways in which fMRI data can be used to seed dipole sources for ERP data, and the ways in which these sources can be disentangled. Understanding the relationship between neurobiological markers and psychological functioning has large implications for mental health. It provides a potential avenue for new procedures for diagnosis and assessment for the efficacy of treatment for executive dysfunction associated with psychiatric disorders.

这个核心的主要目标是提供大脑映射的专业知识，无论是关于磁 共振成像和电生理技术，用于项目1、2、3和5。核心将 在神经生物学和心理学两个分析层面上进行检查，明确解决 在我们对执行功能的理解中，将分析的各个层次联系起来的中心目标。核心资金将用于： a）MRI和ERP数据的质量控制、存储、分析和存档; B）数据结构和处理程序的文档 c）将新的分析工具纳入数据分析路径 d）进行脑图谱实验的支持人员 （e）培训这些研究方法以及编写培训材料 f）为数据共享准备数据，以及其他相关职能 关于神经成像，该核心还将提供： a）安装系统升级和硬件改进 B）开发新的采集和预处理方法，特别是那些处理 敏感性伪影和低信噪比。 （c）应用新的统计方法进行数据分析 d）如果在参与者中观察到任何结构异常， 关于电生理技术，该核心还将提供： a）整个高密度阵列记录系统的数据收集标准化 B）扩展方法和途径，用于整合来自fMRI和ERP实验的数据， 是平行设计的。更具体地说，它将研究功能磁共振成像数据可用于 ERP数据的种子偶极子源，以及这些源可以被解开的方式。 了解神经生物学标记物和心理功能之间的关系， 对心理健康的影响。它为新的诊断程序提供了潜在的途径， 评估与精神障碍相关的执行功能障碍的治疗效果。