Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics

描述（由申请人提供）：本提案要求支持由Joseph M. Metzger, Leslie a . Leinwand和Jeffrey D. Molkentin组织的题为“分子心脏病学：疾病机制和实验治疗”的Keystone专题会议，该会议将于2011年2月22日至27日在科罗拉多州的Keystone举行。这一建议的基本原理和意义在于，通过分子心脏病学领域产生的新的机制见解及其在实验性心血管治疗中的应用，人类健康和保健在全国和全球都得到了改善。会议旨在吸引该领域领先的实验室、研究人员、学生和学员，以解决人类心脏功能基本途径的空白，以及当它们功能失调时，它们如何导致心脏病。这次会议的重要性和影响与平行的Keystone心脏生长、死亡和再生机制专题会议的联合形式一致，进一步扩大了会议的重要性和影响。总的来说，这些会议将讨论调节心脏结构、功能和修复的基本机制以及它们与人类心脏病的关系。这次联合会议的另一个独特之处在于实施并突出了早期独立职业研究竞赛和专门的研究生和博士后研究竞赛。具体目标特点：1)心脏细胞生长的遗传学、表观遗传学、生物化学和生理学方面的见解和争议；2)心脏钙处理的新概念以及新的机制见解如何为新的实验治疗提供信息；3)细胞间和细胞内心脏通讯在健康和疾病中的机制。同时举行的会议形式还旨在实现以下目标：4)促进干细胞生物学家和研究心脏生长、死亡和心脏生理学的个人之间的互动；5)除了通常的讲座和海报展示外，还通过多种机制为学员提供重要的学习经验。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled, Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics organized by Joseph M. Metzger, Leslie A. Leinwand and Jeffrey D. Molkentin, which will be held in Keystone, Colorado from February 22 - 27, 2011. The overarching rationale and significance of this proposal is that human health and wellness are advanced, both nationally and globally, by new mechanistic insights emanating from the field of molecular cardiology and its application to experimental cardiovascular therapeutics. The meeting is designed to attract leading laboratories, investigators, students and trainees in the field to address gaps in fundamental pathways in human heart functionality and how, when they become dysfunctional, they contribute to cardiac disease. The significance and impact of this meeting is further amplified by aligning in joint format with a parallel Keystone Symposia meeting on Mechanisms of Cardiac Growth, Death and Regeneration. Collectively, these meetings will address the fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human heart disease. Another unique feature of this joint meeting stems from implementing and highlighting an Early Independent Career Research Competition and a dedicated Graduate Student and Postdoc Research Competition. Specific Objectives feature: 1) insights and controversies in the genetics, epigenetics and the biochemistry and physiology of cardiac cell growth; 2) emerging concepts in cardiac calcium handling and how new mechanistic insights are informing novel experimental therapeutics; and 3) mechanisms of inter- and intra- cellular cardiac communication in health and disease. The concurrent meeting format also aims to accomplish the following: 4) stimulate interactions among stem cell biologists and individuals studying cardiac growth, death and cardiac physiology; and 5) provide trainees with a significant learning experience through several mechanisms in addition to the usual lectures and poster presentations. PUBLIC HEALTH RELEVANCE: Myocardial ischemia and heart failure are the most common causes of mortality in the United States and the world. This Keystone Symposia meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics is designed to attract the leading laboratories, investigators, students and trainees in the field to address gaps in our understanding of fundamental pathways in human heart functionality and how, when they become dysfunctional, they contribute to cardiac disease. This meeting - held in tandem with a meeting on Mechanisms of Cardiac Growth, Death and Regeneration - will involve scientific questions relevant both to the cardiovascular system and stem cell biology as a whole.