Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics

分子心脏病学：疾病机制和实验治疗

• 批准号: 8061261
• 负责人: ANDREW D ROBERTSON
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061261
• 关键词: Address; Biochemistry; Biology; Calcium; Cardiac; Cardiac Death; Cardiology; Cardiovascular system; Cell Communication; Cell Death; Cessation of life; Colorado; Communication; Data; Disease; Epigenetic Process; Faculty; Functional disorder; Genes; Genetic; Goals; Growth; Health; Heart; Heart Diseases; Heart Hypertrophy; Heart failure; Human; Individual; Joints; Laboratories; Learning; Medical; Molecular; Myocardial Infarction; Myocardial Ischemia; Natural regeneration; Outcome; Participant; Pathway interactions; Performance; Physiology; Postdoctoral Fellow; Request for Proposals; Research; Research Personnel; Shapes; Societies; Staging; Stem cells; Structure; Students; Syndrome; Therapeutic; Translating; United States; abstracting; career; cell growth; design; empowered; experience; graduate student; infancy; insight; lectures; meetings; mortality; next generation; novel; posters; programs; repaired; stem; stem cell biology; symposium

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled, Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics organized by Joseph M. Metzger, Leslie A. Leinwand and Jeffrey D. Molkentin, which will be held in Keystone, Colorado from February 22 - 27, 2011. The overarching rationale and significance of this proposal is that human health and wellness are advanced, both nationally and globally, by new mechanistic insights emanating from the field of molecular cardiology and its application to experimental cardiovascular therapeutics. The meeting is designed to attract leading laboratories, investigators, students and trainees in the field to address gaps in fundamental pathways in human heart functionality and how, when they become dysfunctional, they contribute to cardiac disease. The significance and impact of this meeting is further amplified by aligning in joint format with a parallel Keystone Symposia meeting on Mechanisms of Cardiac Growth, Death and Regeneration. Collectively, these meetings will address the fundamental mechanisms that regulate cardiac structure, function, and repair and how they relate to human heart disease. Another unique feature of this joint meeting stems from implementing and highlighting an Early Independent Career Research Competition and a dedicated Graduate Student and Postdoc Research Competition. Specific Objectives feature: 1) insights and controversies in the genetics, epigenetics and the biochemistry and physiology of cardiac cell growth; 2) emerging concepts in cardiac calcium handling and how new mechanistic insights are informing novel experimental therapeutics; and 3) mechanisms of inter- and intra- cellular cardiac communication in health and disease. The concurrent meeting format also aims to accomplish the following: 4) stimulate interactions among stem cell biologists and individuals studying cardiac growth, death and cardiac physiology; and 5) provide trainees with a significant learning experience through several mechanisms in addition to the usual lectures and poster presentations. PUBLIC HEALTH RELEVANCE: Myocardial ischemia and heart failure are the most common causes of mortality in the United States and the world. This Keystone Symposia meeting on Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics is designed to attract the leading laboratories, investigators, students and trainees in the field to address gaps in our understanding of fundamental pathways in human heart functionality and how, when they become dysfunctional, they contribute to cardiac disease. This meeting - held in tandem with a meeting on Mechanisms of Cardiac Growth, Death and Regeneration - will involve scientific questions relevant both to the cardiovascular system and stem cell biology as a whole.

描述(由申请人提供)：本提案请求支持将于2011年2月22-27日在科罗拉多州Keystone举行的题为“分子心脏病学：疾病机制和实验治疗学”的Keystone研讨会，该会议由Joseph M.Metzger、Leslie A.Leinwand和Jeffrey D.Molkentin组织。这一建议的主要理论基础和意义是，分子心脏病学领域及其在实验性心血管治疗中的应用所产生的新的机械论见解，促进了人类的健康和健康，无论是在国内还是在全球。这次会议旨在吸引该领域的领先实验室、研究人员、学生和受训人员，以解决人类心脏功能基本途径方面的差距，以及当这些途径功能失调时，它们如何导致心脏病。通过与关于心脏生长、死亡和再生机制的平行Keystone研讨会相结合，进一步扩大了这次会议的意义和影响。总的来说，这些会议将讨论调节心脏结构、功能和修复的基本机制，以及它们与人类心脏病的关系。这次联席会议的另一个独特之处在于实施和突出了早期独立职业研究竞赛和专门的研究生和博士后研究竞赛。具体目标特征：1)在遗传学、表观遗传学以及心肌细胞生长的生物化学和生理学方面的见解和争议；2)心脏钙处理方面的新概念以及新的机制见解如何提供新的实验疗法；以及3)健康和疾病中细胞间和细胞内心脏通讯的机制。同时举行的会议形式还旨在实现以下目标：4)促进干细胞生物学家和研究心脏生长、死亡和心脏生理学的个人之间的互动；以及5)除了通常的讲座和海报演示外，通过几种机制为学员提供重要的学习经验。 公共卫生相关性：心肌缺血和心力衰竭是美国和世界上最常见的死亡原因。这次关于分子心脏病学：疾病机制和实验治疗学的Keystone研讨会旨在吸引该领域的领先实验室、研究人员、学生和受训人员，以解决我们对人类心脏功能的基本途径以及当这些途径功能失调时它们如何导致心脏疾病的理解方面的差距。这次会议与关于心脏生长、死亡和再生机制的会议同时举行，将涉及与心血管系统和整个干细胞生物学相关的科学问题。