Cancer and Metabolism

描述(由申请人提供)：本提案请求支持由鲁本·J·肖和大卫·M·萨巴蒂尼组织的题为癌症和新陈代谢的Keystone研讨会，会议将于2012年2月12-17日在加拿大艾伯塔省班夫举行。虽然20世纪20年代奥托·沃伯格首次指出葡萄糖代谢改变是肿瘤细胞的特征，但这一观察的分子基础直到过去十年才开始得到充分认识。在过去的五年里，随着真正的抑癌基因和癌基因与代谢控制的广泛相互作用的鉴定，这一领域已经爆炸式增长。肿瘤细胞生物合成需求的增加要求细胞新陈代谢的重新编程，这也增加了能量需求，使肿瘤细胞更容易受到针对其新陈代谢的干预。关于癌症和代谢的Keystone研讨会会议的目标是将癌症和代谢控制领域的领导者与那些研究相互联系和控制的信号通路的人聚集在一起。将讨论最新的发现，以及如何利用这些知识来设计未来的癌症治疗方法。同时举行的低氧信号进展会议：从长凳到床边，将显著增加跨学科互动的机会，该会议将与本次会议共享主旨演讲和全体会议。 公共卫生相关性：大多数肿瘤都经历了代谢改变--这一特征可用于非侵入性监测肿瘤的生长、进展和治疗反应。随着肿瘤细胞经历更多的能量需求，它们更容易受到针对其新陈代谢的干预；目前正在进行重大努力，以开发针对这种癌细胞特异性敏感性的治疗方法。关于癌症和代谢的Keystone研讨会会议将把癌症和代谢控制领域的领导者与那些研究相互联系和控制的信号通路的人聚集在一起。将讨论最新的发现，以及如何利用这些知识来设计未来的癌症治疗方法。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Cancer and Metabolism, organized by Reuben J. Shaw and David M. Sabatini, which will be held in Banff, Alberta, Canada from February 12 - 17, 2012. Although altered glucose metabolism was first noted as a characteristic of tumor cells by Otto Warburg in the 1920s, the molecular underpinning for this observation did not begin to be appreciated fully until the past decade. And this area has exploded over the last five years with the identification of extensive interactions of genuine tumor suppressor genes and oncogenes with metabolic control. The increased biosynthetic needs of tumor cells demands a reprogramming of cellular metabolism, which also creates increased energy demands and makes tumor cells more vulnerable to interventions targeting their metabolism. The goal of the Keystone Symposia meeting on Cancer and Metabolism is to bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Advances in Hypoxic Signaling: From Bench to Bedside, which will share a keynote address and a plenary session with this meeting. PUBLIC HEALTH RELEVANCE: Most tumors undergo altered metabolism - a feature that can be used to non-invasively monitor tumor growth, progression, and therapeutic response. As tumor cells experience increased energy demands they become more vulnerable to interventions targeting their metabolism; major efforts are underway to develop therapeutics to target this cancer cell-specific sensitivity. The Keystone Symposia meeting on Cancer and Metabolism will bring together leaders in the fields of cancer and metabolic control with those studying the signaling pathways linking and governing each. The latest discoveries will be discussed as well as how this knowledge can be exploited to design future cancer therapeutics.