Molecular Basis of Vascular Inflammation and Atherosclerosis

描述（由申请人提供）：本提案要求支持由Edward a . Fisher, Catherine C. Hedrick和MacRae F. Linton组织的题为血管炎症和动脉粥样硬化分子基础的Keystone专题会议，该会议将于2012年3月25日至30日在蒙大拿州Big Sky举行。炎症不可避免地与动脉粥样硬化的自然历史交织在一起。巨噬细胞在动脉粥样硬化的发病机制中不可或缺，在炎症和胆固醇稳态的交叉点起作用，使其生物学特性成为一个重要的话题。因此，巨噬细胞生物学将成为血管炎症和动脉粥样硬化分子基础专题讨论会的主要焦点。还将回顾先天免疫和适应性免疫对动脉粥样硬化的重要贡献，并将讨论炎症过程的基本特征，包括其解决方案，并将介绍可能影响动脉粥样硬化领域未来范式的概念。最近发现的调节动脉粥样硬化脂蛋白水平的因素，动脉炎症的关键发起者，将被提出。其他亮点包括发现冠状动脉疾病危险因素的基因组方法的进展，以及检测动脉粥样硬化斑块、斑块细胞组成和体内免疫细胞运输的成像技术的进展。主题演讲将强调核激素受体作为斑块脂质代谢和免疫活性整合体的新作用。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Molecular Basis of Vascular Inflammation and Atherosclerosis, organized by Edward A. Fisher, Catherine C. Hedrick and MacRae F. Linton, which will be held in Big Sky, Montana from March 25 - 30, 2012. Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques, and trafficking of immune cells in vivo. The Keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity. PUBLIC HEALTH RELEVANCE: Atherosclerosis and cardiovascular disease remain leading causes of death in the United States. Moreover, atherosclerosis is a major risk factor for subjects with Type 2 diabetes, and the incidence of Type 2 diabetes onset is increasing at an alarming rate worldwide. The Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis is focused on three fields that are emerging in atherosclerosis research - immunology, genetics, and imaging - and includes speakers who are performing cutting-edge research in these fields and are now bringing their expertise to atherosclerosis. The goal of this conference is to provide both trainees and faculty studying atherosclerosis and cardiovascular disease with the opportunity to learn, to exchange ideas in a positive environment, and to forge collaborations.