Molecular Basis of Vascular Inflammation and Atherosclerosis

描述(由申请人提供)：本提案请求支持由Edward A.Fisher、Catherine C.Hedrick和Macrae F.Linton组织的题为《血管炎症和动脉粥样硬化的分子基础》的Keystone研讨会，该会议将于2012年3月25-30日在蒙大拿州的Big Sky举行。炎症不可避免地与动脉粥样硬化的自然历史交织在一起。巨噬细胞是动脉粥样硬化发病机制中不可或缺的一部分，在炎症和胆固醇动态平衡的交界处发挥作用，使其生物学特性成为一个重要的课题。因此，巨噬细胞生物学将是关于血管炎症和动脉粥样硬化的分子基础的Keystone研讨会的主要焦点。还将回顾先天免疫和获得性免疫对动脉粥样硬化的关键贡献，并将介绍可能影响动脉粥样硬化领域未来范式的概念，包括炎症过程的基本特征，包括其解决方案。最近发现的调节致动脉粥样硬化性脂蛋白水平的因素，动脉炎症的关键启动者，将被提出。其他亮点包括发现冠状动脉疾病危险因素的基因组方法的进展，以及检测动脉粥样硬化斑块、斑块的细胞组成和体内免疫细胞运输的成像技术的进展。主旨演讲将强调核激素受体作为斑块、脂质代谢和免疫活动的整合因子的新角色。 公共卫生相关性：动脉粥样硬化和心血管疾病仍然是美国的主要死亡原因。此外，动脉粥样硬化是2型糖尿病患者的主要危险因素，全球2型糖尿病的发病率正在以惊人的速度增长。关于血管炎症和动脉粥样硬化的分子基础的Keystone研讨会会议聚焦于动脉粥样硬化研究中出现的三个领域-免疫学、遗传学和成像-包括在这些领域进行尖端研究并正在将他们的专业知识带到动脉粥样硬化领域的演讲者。本次会议的目标是为研究动脉粥样硬化和心血管疾病的实习生和教职员工提供学习的机会，在积极的环境中交流思想，并建立合作关系。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Molecular Basis of Vascular Inflammation and Atherosclerosis, organized by Edward A. Fisher, Catherine C. Hedrick and MacRae F. Linton, which will be held in Big Sky, Montana from March 25 - 30, 2012. Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques, and trafficking of immune cells in vivo. The Keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity. PUBLIC HEALTH RELEVANCE: Atherosclerosis and cardiovascular disease remain leading causes of death in the United States. Moreover, atherosclerosis is a major risk factor for subjects with Type 2 diabetes, and the incidence of Type 2 diabetes onset is increasing at an alarming rate worldwide. The Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis is focused on three fields that are emerging in atherosclerosis research - immunology, genetics, and imaging - and includes speakers who are performing cutting-edge research in these fields and are now bringing their expertise to atherosclerosis. The goal of this conference is to provide both trainees and faculty studying atherosclerosis and cardiovascular disease with the opportunity to learn, to exchange ideas in a positive environment, and to forge collaborations.