Molecular Basis of Vascular Inflammation and Atherosclerosis

血管炎症和动脉粥样硬化的分子基础

• 批准号: 8253848
• 负责人: James Wavell Aiken
• 金额: $ 1.38万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8253848
• 关键词: Address; Area; Arterial Fatty Streak; Atherosclerosis; Biological; Biology; Cardiovascular Diseases; Cause of Death; Cells; Cholesterol Homeostasis; Collaborations; Coronary Arteriosclerosis; Environment; Faculty; Future; Genetic; Genomics; Goals; Image; Imaging Techniques; Immune; Immunology; Incidence; Inflammation; Inflammatory; Learning; Lipoproteins; Metabolism; Molecular; Montana; Natural History; Natural Immunity; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Hormone Receptors; Outcome; Participant; Pathogenesis; Process; Property; Request for Proposals; Research; Resolution; Risk Factors; Role; United States; adaptive immunity; base; career; forging; in vivo; lipid metabolism; macrophage; meetings; molecular imaging; novel; symposium; therapy development; trafficking; vascular inflammation

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Molecular Basis of Vascular Inflammation and Atherosclerosis, organized by Edward A. Fisher, Catherine C. Hedrick and MacRae F. Linton, which will be held in Big Sky, Montana from March 25 - 30, 2012. Inflammation is inextricably woven into the natural history of atherosclerosis. The macrophage is integral to the pathogenesis of atherosclerosis, functioning at the intersection of inflammation and cholesterol homeostasis, making its biological properties an important topic. Consequently, macrophage biology will be a major focus of the Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis. The critical contributions of innate and adaptive immunities to atherosclerosis will also be reviewed, and a session on fundamental features of the inflammatory process, including its resolution, will introduce concepts likely to influence future paradigms in the atherosclerosis field. Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented. Other highlights include progress in genomic approaches to discover risk factors for coronary artery disease, as well as advances in imaging techniques to detect atherosclerotic plaques, cellular composition of plaques, and trafficking of immune cells in vivo. The Keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity. PUBLIC HEALTH RELEVANCE: Atherosclerosis and cardiovascular disease remain leading causes of death in the United States. Moreover, atherosclerosis is a major risk factor for subjects with Type 2 diabetes, and the incidence of Type 2 diabetes onset is increasing at an alarming rate worldwide. The Keystone Symposia meeting on Molecular Basis of Vascular Inflammation and Atherosclerosis is focused on three fields that are emerging in atherosclerosis research - immunology, genetics, and imaging - and includes speakers who are performing cutting-edge research in these fields and are now bringing their expertise to atherosclerosis. The goal of this conference is to provide both trainees and faculty studying atherosclerosis and cardiovascular disease with the opportunity to learn, to exchange ideas in a positive environment, and to forge collaborations.

描述（由申请人提供）：本提案请求支持由Edward A.作者：Catherine C.赫德里克和麦克雷F.林顿，将于2012年3月25日至30日在蒙大拿州的大天空举行。炎症是不可分割地编织到动脉粥样硬化的自然史。巨噬细胞是动脉粥样硬化发病机制的组成部分，在炎症和胆固醇稳态的交叉点发挥作用，使其生物学特性成为一个重要的课题。因此，巨噬细胞生物学将是血管炎症和动脉粥样硬化的分子基础的基石研讨会会议的主要焦点。先天免疫和适应性免疫对动脉粥样硬化的重要贡献也将被回顾，炎症过程的基本特征，包括其解决方案，将介绍可能影响动脉粥样硬化领域未来范式的概念。最近发现的因素，调节致动脉粥样硬化脂蛋白，动脉炎症的关键发起人的水平，将提出。其他亮点包括发现冠状动脉疾病危险因素的基因组方法的进展，以及检测动脉粥样硬化斑块、斑块细胞组成和体内免疫细胞运输的成像技术的进展。主题演讲将强调核激素受体作为斑块脂质代谢和免疫活性的整合剂的新作用。 公共卫生相关性：动脉粥样硬化和心血管疾病仍然是美国的主要死亡原因。此外，动脉粥样硬化是患有2型糖尿病的受试者的主要危险因素，并且2型糖尿病发作的发病率在世界范围内以惊人的速度增加。血管炎症和动脉粥样硬化的分子基础的Keystone研讨会会议集中在动脉粥样硬化研究中出现的三个领域-免疫学，遗传学和成像-包括在这些领域进行尖端研究的发言者，现在正在将他们的专业知识带到动脉粥样硬化。本次会议的目标是为研究动脉粥样硬化和心血管疾病的学员和教师提供学习的机会，在积极的环境中交流思想，并建立合作。