Fungal Pathogens: From Basic Biology to Drug Discovery

产品说明： 本申请请求支持由约瑟夫·海特曼、约翰·泰勒和莉亚·E·埃克曼组织的题为“真菌病原体：从基础生物学到药物发现”的基石研讨会。考恩，将于2012年1月15日至20日在新墨西哥州圣达菲举行。本次会议的目的是汇集学术，医学和制药界专注于人类和其他动物的真菌微生物病原体，以说明共同的主题，以及治疗，诊断和预防的机会。在基础科学家和医学科学家中，我们寻求那些致力于病原微生物（通过遗传学，细胞生物学，基因组学）和宿主（免疫学，包括先天免疫和适应性免疫）的人。在治疗方面，重点是开发和新的治疗方法，包括药物和疫苗。最后，一个关键的方面是将致力于感染人类的真菌多样性的社区与致力于引起两栖动物减少和灭绝的壶菌爆发的社区联系起来。跨学科互动的机会将显着提高药物发现原生动物寄生虫，这将与本次会议分享一个主旨演讲和两个全体会议的并行会议。 公共卫生相关性： 迫切需要更好地了解无处不在的真菌病原体的生物学。它们不仅是危及生命的人类疾病的原因：它们也是两栖动物灭绝的原因，对农业和世界粮食供应构成威胁，并且是生物武器的潜在风险。关于真菌病原体的Keystone研讨会会议：从基础生物学到药物发现将提供一个独特的场所，从跨学科的角度对不同的真菌病原体进行互动和前沿研究交流，包括进化，基因组学，毒力机制，宿主-病原体相互作用，性遗传交换，耐药性和药物发现。

DESCRIPTION: This application requests support for a Keystone Symposia meeting entitled Fungal Pathogens: From Basic Biology to Drug Discovery, organized by Joseph Heitman, John Taylor and Leah E. Cowen, which will be held in Santa Fe, New Mexico from January 15 - 20, 2012. The aim of this meeting is to bring together the academic, medical, and pharmaceutical communities focused on fungal microbial pathogens of humans and other animals to illustrate common themes, and therapeutic, diagnostic, and preventive opportunities. Among both basic and physician-scientists, we seek to bridge those working on the pathogenic microbe (via genetics, cell biology, genomics) and the host (immunology, including both innate and adaptive immunity). With respect to therapeutics, the emphasis is on developed as well as novel therapeutics, including both drugs and vaccines. Finally, a key aspect is to bridge the communities working on the diversity of fungi that infect humans, and also those working on the chytrid outbreak causing amphibian decline and extinctions. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Drug Discovery for Protozoan Parasites, which will share a keynote address and two plenary sessions with this meeting. PUBLIC HEALTH RELEVANCE: There is a pressing need to better understand the biology of the pervasive fungal pathogens. These are not only the cause of life-threatening human disease: they are also responsible for amphibian extinctions, present threats to agriculture and world food supplies, and are potential risks as bioweapons. The Keystone Symposia meeting on Fungal Pathogens: From Basic Biology to Drug Discovery will provide a unique venue for interaction and exchange of cutting-edge research on diverse fungal pathogens from an interdisciplinary perspective spanning evolution, genomics, mechanisms of virulence, host-pathogen interactions, sexual genetic exchange, drug resistance and drug discovery.