Hematopoiesis

描述(由申请者提供)：请求支持由Leonard I.Zon、Stuart H.Orkin和Nancy A.SPECK组织的题为造血的Keystone研讨会，该会议将于2013年1月14-19日在科罗拉多州斯普林斯举行。造血是指造血干细胞自我更新和分化形成外周血细胞系的过程。这次会议试图从自我更新过程、造血系统的发展和分化方面对这一过程形成一个宽泛的看法。全体会议将围绕造血干细胞的诞生，一直到成年后成熟细胞谱系的发展。它们将包括探索胚胎血液系统诞生的发育中造血的会议，关于成人干细胞自我更新的会议，以及关于干细胞利基和新型造血调节剂的会议。会议将涉及的特别令人兴奋的研究领域包括识别新的促进干细胞决策的生长因子，利用新的遗传和基因组技术了解转录机制的进展，以及调节白血病干细胞群体的新的表观遗传机制。会议还将讨论正在为临床试验制定的药物战略。综上所述，我们预计这次会议将对造血干细胞及其后代在控制癌症和疾病方面的生物学和潜在治疗用途产生新的见解。与公共健康相关：造血是造血干细胞--产生所有血细胞类型的细胞--自我更新和分化为外周血统的过程。在美国，每年有近10,000人的死亡直接归因于与血液相关的疾病，而血液和造血系统的功能障碍在美国造成了太多的主要死亡原因，包括心血管疾病、癌症、糖尿病和中风。关于造血的Keystone研讨会会议将聚集国际公认的研究人员，他们致力于血细胞发育、恶性肿瘤和贫血，以新出现的数据为基础开发新的假设。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Hematopoiesis, organized by Leonard I. Zon, Stuart H. Orkin and Nancy A. Speck, which will be held in Steamboat Springs, Colorado from January 14 - 19, 2013. Hematopoiesis is the process by which hematopoietic stem cells self-renew and differentiate to form the peripheral blood lineages. This meeting seeks to develop a broad view of this process in terms of the self- renewal process, development of the hematopoietic system, and differentiation. Plenary sessions will encompass the birth of hematopoietic stem cells all the way through development of mature cell lineages throughout adult life. They will include sessions on developmental hematopoiesis that will explore the birth of the blood system in embryos, sessions on adult stem cell self-renewal, and sessions on stem cell niches and novel hematopoietic regulators. Particularly exciting areas of research that will be covered in the meeting include the identification of new growth factors that enhance stem cell decisions, advances in our understanding of transcription mechanisms using new genetic and genomic technologies, and new epigenetic mechanisms that regulate leukemic stem cell populations. The meeting will also address drug strategies that are being developed for clinical trials. Taken together, we anticipate that this conference will yield novel insights into the biology and potentil therapeutic uses of hematopoietic stem cells and their progeny for the control of cancer and disease. PUBLIC HEALTH RELEVANCE: Hematopoiesis is the process by which hematopoietic stem cells - the cells that give rise to all blood cell types - self-renew and differentiate to for the peripheral blood lineages. In the United States, nearly 10,000 deaths annually are directly attributable to blood-related diseases, and dysfunction of the blood and blood-forming system contributes too many of the leading causes of death in the U.S., including cardiovascular disease, cancer, diabetes and stroke. The Keystone Symposia meeting on Hematopoiesis will gather internationally recognized investigators who work on blood cell development, malignancy, and anemias to develop new hypotheses based on emerging data.