Cell Biology of Virus Entry, Replication and Pathogenesis

产品说明： 本申请请求支持由Michael Farzan、Benhur Lee和Judith M.白色，将于2012年3月26日至31日在加拿大不列颠哥伦比亚省举行。本次会议将突出病毒感染途径的最新进展，并在病毒感染的细胞反应。会议采用广泛的技术和分析水平分析了病毒生命周期的多个阶段。这次会议的一个新特点是，它将与关于艾滋病毒发病机制、治疗和根除前沿的Keystone专题讨论会同时B，因此将侧重于最大限度地加强艾滋病毒界与更广泛的病毒学家界之间的交流。一个明确的目标是将那些原本可能不会在更专门的会议上互动的研究人员聚集在一起，并促进他们之间的潜在协同作用。一个经典的，几乎是典型的，这种串扰的力量的例子是A型流感病毒血凝素的研究对我们理解HIV-1进入过程的贡献，以及随后两个系统对我们理解I型融合，II型融合和无包膜病毒进入过程的贡献。因此，两个共同的会议将集中在逆转录病毒的进入过程及其抑制，其次是会谈特色的病毒进入，复制，结构和系统的方法，病毒学，宿主免疫逃避和治疗更广泛的调查。 公共卫生相关性： 尽管我们对病毒和病毒发病机制（病毒如何在宿主体内引起疾病）的理解取得了令人印象深刻的进展，但病毒仍然是一个持续的公共卫生问题，它们有可能导致更严重和更具破坏性的大流行病。关于病毒进入、复制和发病机制的细胞生物学的基石研讨会会议，以及同时举行的关于艾滋病毒发病机制、治疗和根除前沿的会议，将为批判性地审查病毒学最新研究以及促进艾滋病毒社区和更广泛的病毒学家社区之间的互动提供一个跨学科平台。

DESCRIPTION: This application requests support for a Keystone Symposia meeting entitled Cell Biology of Virus Entry, Replication and Pathogenesis, organized by Michael Farzan, Benhur Lee and Judith M. White, which will be held in British Columbia, Canada from March 26 - 31, 2012. This meeting will highlight recent advances in virus infection pathways, and in the cellular responses to viral infection. The meeting features multiple stages of the viral lifecycle analyzed using a broad array of techniques and levels of analysis. A novel feature of this meeting is that it will b held concurrently with the Keystone Symposia meeting on Frontiers in HIV Pathogenesis, Therapy and Eradication and will, therefore, focus on maximizing exchange between the HIV community and the broader community of virologists. An explicit goal is to bring together and promote potential synergies among researchers who might not otherwise interact in more specialized meetings. A classic, almost paradigmatic, example of the power of this cross-talk is the contribution of studies of influenza A virus hemagglutinin to our understanding of the HIV-1 entry process, and the subsequent contribution of both systems to our understanding of type I fusion, type II fusion, and to the entry processes non-enveloped viruses. Accordingly, two common sessions will focus on the retroviral entry process and its inhibition, followed by talks featuring a broader survey of viral entry, replication, structural and systems approaches to virology, host immune evasion, and therapeutics. PUBLIC HEALTH RELEVANCE: Despite impressive advances in our understanding of viruses and viral pathogenesis - how viruses cause diseases in their hosts - viruses remain an ongoing public health concern, and they have the potential to cause even more serious and disruptive pandemics. The Keystone Symposia meeting on Cell Biology of Virus Entry, Replication and Pathogenesis - in combination with a concurrent meeting on Frontiers in HIV Pathogenesis, Therapy and Eradication - will provide a cross-disciplinary platform for critically examining recent research i virology, as well as promoting interactions between the HIV community and the broader community of virologists.