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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
8349232
负责人：
Heidi Kong
金额：
$3.38万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349232
关键词：
BiopsyClinicalCutaneousCytochrome P450DataDiureticsDoxycyclineGene ExpressionGene Expression ProfilingGenotypeGoalsImmunohistochemistryLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityProtocols documentationReactionRecommendationRoleSignal TransductionSkinSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteertranslational approachultraviolet

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英文摘要
In fiscal year 2011, we continued to validate our microarray data obtained from skin biopsies of skin phototoxicity. The initial analysis demonstrated that there were gene expression signals in skin treated with doxycycline alone (without ultraviolet or light exposure) compared to control skin. We amended our protocol in 2010 to allow us to re-treat healthy volunteers with doxycycline to obtain additional biopsies. We treated 4 additional healthy volunteers in fiscal year 2011. We have been performing immunohistochemistry on these additional biopsies to validate the microarray data.
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