Autophagy: Fundamentals to Disease

描述（由申请人提供）：要求支持由Christina H. Eng, Daniel J. Klionsky， Guido Kroemer和Li Yu组织的题为“自噬：疾病基础”的Keystone专题会议。会议将于2014年5月23日至28日在德克萨斯州奥斯汀举行。自噬是一个基本的细胞过程，在基础和细胞或环境应激条件下协调蛋白质、脂质和细胞器的降解。自噬曾被认为只发生在营养不足的时候，但它显然在发育和病理情况下都起着重要作用。随着自噬在多种疾病中的重要性逐渐显现，需要深入了解自噬的主要途径和替代途径，才能充分理解和有效调节自噬。本次会议将重点介绍自噬研究的前沿，从基本的机制见解和信号传导到自噬在多种疾病领域的作用和治疗靶向的前景。讨论的重点领域将包括自噬体膜的来源，巨噬和有丝自噬的新机制见解，以及自噬在正常和疾病情况下的关键作用，如癌症，神经退行性疾病，克罗恩病，溶酶体贮存病，心肌病和衰老。研究自噬在疾病中的作用将使我们能够理解在哪些情况下调节自噬可能是有益的，并确定控制自噬的核心过程将使我们能够确定调节途径的工具。本次会议将汇集各种研究人员探索自噬的不同方面，他们的相互作用将扩大我们对不同背景下基本自噬机制及其在生理和病理环境中的关键功能的认识。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Autophagy: Fundamentals to Disease, organized by Christina H. Eng, Daniel J. Klionsky, Guido Kroemer and Li Yu. The meeting will be held in Austin, Texas from May 23-28, 2014. Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn's disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.