Autophagy: Fundamentals to Disease

描述(由申请人提供)：请求支持由Christina H.Eng、Daniel J.Klion sky、Guido Kroemer和李钰组织的题为自噬：疾病的基本原理的Keystone研讨会。会议将于2014年5月23日至28日在得克萨斯州奥斯汀举行。自噬是一种基本的细胞过程，它在基础和细胞或环境应激条件下协调蛋白质、脂类和细胞器的降解。自噬曾经被认为只发生在营养受限的时候，显然在发育和病理情况下都发挥着重要作用。由于自噬在各种疾病中的重要性正在显现，需要深入了解主要的和替代的自噬途径，以充分理解和有效地调节自噬。自噬研究的前沿将在这次会议上突出，从基本的机械学见解和信号到自噬在多个疾病领域中所起的作用和治疗靶向的前景。主要讨论领域包括自噬体膜的来源，对巨噬和有丝分裂吞噬的新的机械学见解，以及自噬在正常和疾病情况下的关键作用，如癌症、神经退行性疾病、克罗恩病、溶酶体储存疾病、心肌病和衰老。研究自噬在疾病中的作用将使我们能够在哪些情况下调制自噬可能是有益的，并且识别控制自噬的核心过程将使我们能够识别调节该途径的工具。这次会议将聚集探索自噬不同方面的不同研究人员，他们的互动将扩大我们对不同背景下的基本自噬机制及其在生理和病理环境中的关键功能的知识。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Autophagy: Fundamentals to Disease, organized by Christina H. Eng, Daniel J. Klionsky, Guido Kroemer and Li Yu. The meeting will be held in Austin, Texas from May 23-28, 2014. Autophagy is a fundamental cellular process that orchestrates the degradation of proteins, lipids and organelles during both basal and cellular or environmental stress conditions. Once thought to occur only during times of nutrient limitation, autophagy clearly plays major roles in both developmental and pathological situations. As the importance of autophagy in a variety of diseases is emerging, an in-depth knowledge of primary and alternative autophagic pathways is required to fully understand and effectively modulate it. The forefront of autophagy research will be highlighted at this meeting, from basic mechanistic insights and signaling to the role autophagy plays in multiple disease areas and prospects for therapeutic targeting. Key areas of discussion will include the source of the autophagosomal membrane, new mechanistic insights into both macroautophagy and mitophagy, and the critical roles of autophagy in normal and disease situations such as cancer, neurodegenerative diseases, Crohn's disease, lysosomal storage diseases, cardiomyopathy and aging. Examining the role of autophagy in disease will enable us to understand in contexts in which modulation of autophagy may be beneficial, and identifying the core processes that control autophagy will enable us to identify tools to modulate the pathway. This meeting will bring together a variety of investigators exploring different facets of autophagy, and their interactions will expand our knowledge of fundamental autophagic mechanisms in different contexts and their critical functions in physiological and pathological settings.