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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
8937893
负责人：
Heidi Kong
金额：
$1.12万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8937893
关键词：
BiopsyClinicalCutaneousCytochrome P450Data AnalysesDiureticsDoxycyclineGene ExpressionGene Expression ProfilingGenotypeGoalsHuman ResourcesLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityProtocols documentationReactionRecommendationRoleSerumSkinStaining methodStainsSunscreening AgentsTestingUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteertranslational approachultraviolet

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In 2010, the protocol was amended to allow us to treat a subset of returning healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of the additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of the additional biopsies obtained from healthy volunteers treated with doxycycline. In fiscal year 2013, we investigated the serum levels of doxycycline from the healthy volunteers who participated in the study in previous years. In fiscal year 2014, we have been unable to analyze the data further due to insufficient personnel.
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