Gene Expression Profiling and Clinical Characterization of Phototoxicity

光毒性的基因表达谱和临床特征

• 批准号: 8937893
• 负责人: Heidi Kong
• 金额: $ 1.12万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8937893
• 关键词: Biopsy; Clinical; Cutaneous; Cytochrome P450; Data Analyses; Diuretics; Doxycycline; Gene Expression; Gene Expression Profiling; Genotype; Goals; Human Resources; Light; Microarray Analysis; Non-Steroidal Anti-Inflammatory Agents; Pathway interactions; Pharmaceutical Preparations; Phototoxicity; Protocols documentation; Reaction; Recommendation; Role; Serum; Skin; Staining method; Stains; Sunscreening Agents; Testing; Ultraviolet Rays; Visible Radiation; Voriconazole; antimicrobial; healthy volunteer; translational approach; ultraviolet

In 2010, the protocol was amended to allow us to treat a subset of returning healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of the additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of the additional biopsies obtained from healthy volunteers treated with doxycycline. In fiscal year 2013, we investigated the serum levels of doxycycline from the healthy volunteers who participated in the study in previous years. In fiscal year 2014, we have been unable to analyze the data further due to insufficient personnel.

2010年，该方案进行了修订，允许我们用强力霉素治疗一部分返回的健康志愿者，以获得额外的活检。2011年，我们完成了额外健康志愿者的治疗。2012年，我们完成了对接受强力霉素治疗的健康志愿者的额外活检组织的免疫组织化学染色分析。在2013财政年度，我们调查了前几年参与研究的健康志愿者的多西环素血清水平。在2014财年，由于人手不足，我们无法进一步分析数据。