Innate Immunity Metabolism and Vascular Injury

先天免疫代谢与血管损伤

• 批准号: 8635912
• 负责人: DAVID L. WOODLAND
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-15 至 2015-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8635912
• 关键词: Adipose tissue; Apoptosis; Apoptotic; Area; Atherosclerosis; Biology; Blood Vessels; British Columbia; Canada; Cardiovascular Diseases; Cells; Chronic; Collaborations; Complement; Complications of Diabetes Mellitus; Coronary Arteriosclerosis; Development; Environment; Fatty acid glycerol esters; Future; Genomics; Goals; Immune system; Inflammation; Inflammatory Response; Injury; Insulin Resistance; Investigation; Knowledge; Lipids; Macrophage Activation; Mediating; Metabolic; Metabolic Diseases; Metabolic stress; Metabolism; Methodology; Modality; Morbidity - disease rate; Myeloid Cells; Natural Immunity; Necrosis; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pathway interactions; Postdoctoral Fellow; Research; Research Personnel; Scientist; Students; Systems Biology; Techniques; Therapeutic; Tissues; Training; clinical practice; disease mechanisms study; improved; interdisciplinary approach; macrophage; meetings; monocyte; mortality; new therapeutic target; public health relevance; symposium; trafficking; vascular bed; vascular inflammation

ABSTRACT Support is requested for a Keystone Symposia meeting entitled Innate Immunity, Metabolism and Vascular Injury, organized by Ajay Chawla, Peter Tontonoz and Gwendalyn J. Randolph. The meeting will be held in Whistler, British Columbia, Canada from March 23-28, 2014. A chronic low-grade inflammatory response is a defining feature of various cardiovascular and metabolic diseases, including atherosclerosis, obesity, and type 2 diabetes. This smoldering inflammation in tissues, whether it is in the vascular bed, white adipose tissue or perivascular fat, is primarily mediated by the innate immune system. Consequently, this meeting will bring together leading investigators in areas of macrophage biology, vascular inflammation, atherosclerosis, and obesity-induced metabolic disease. Sessions will encompass a broad range of topics highlighting the importance of and mechanisms by which innate immunity contributes to progression of cardiovascular and metabolic diseases, including monocyte development and trafficking, macrophage activation in vascular bed and adipose tissues, and systems biology of myeloid cells. Exciting new developments in sensing of metabolic stress by inflammasomes, clearance of apoptotic cells by macrophages, and initiation of necrotic cell death programs will also be discussed. These basic studies will be complemented by talks discussing new strategies for promoting plaque regression, and targeting innate inflammation to treat insulin resistance, type 2 diabetes, and coronary artery disease. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Complications of Diabetes, which will share a two plenary sessions with this meeting.

摘要 要求支持一个名为先天免疫、代谢和血管的Keystone研讨会会议 受伤，由阿贾伊Chawla，彼得Tontonoz和格温达琳J。兰多夫组织。会议将于 2014年3月23日至28日，加拿大不列颠哥伦比亚省惠斯勒。慢性低度炎症反应是一种 各种心血管和代谢疾病的定义特征，包括动脉粥样硬化、肥胖和类型 2糖尿病.这种组织中的闷烧炎症，无论是在血管床，白色脂肪组织或 血管周围脂肪主要由先天免疫系统介导。因此，本次会议将带来 在巨噬细胞生物学、血管炎症、动脉粥样硬化和 肥胖引起的代谢性疾病会议将涵盖广泛的主题，强调 先天免疫促进心血管疾病进展的重要性和机制， 代谢性疾病，包括单核细胞发育和运输，血管床中的巨噬细胞活化 和脂肪组织，以及骨髓细胞的系统生物学。令人兴奋的新发展，在传感代谢 炎性体应激、巨噬细胞清除凋亡细胞和引发坏死性细胞死亡 还将讨论方案。这些基础研究将通过讨论新战略的会谈来补充 用于促进斑块消退和靶向先天性炎症以治疗胰岛素抵抗、2型糖尿病， 和冠心病。跨学科互动的机会将大大增加， 同时举行的糖尿病并发症会议，将与本会议分享两次全体会议。 会议