Beige and Brown Fat: Basic Biology and Novel Therapeutics

描述(由申请者提供)：请求支持由Bruce M.Spiegelman和Sven Enerback组织的题为Beige and Brown Fat：基础生物学和新疗法的Keystone研讨会。会议将于2015年4月17日至22日在犹他州雪鸟举行。肥胖症和糖尿病的流行已成为世界性的健康风险，这些代谢紊乱直接威胁到许多国家的健康和经济福祉。不幸的是，关于饮食和锻炼的教育不足以应对这种紧急情况，迫切需要新的疗法。棕色脂肪已经成为解决这些问题的为数不多的真正新方法之一。棕色脂肪存在于大多数或所有成年人类中，可以在实验动物中分散卡路里能量，减轻肥胖和糖尿病。棕色脂肪(所有类型)在与肥胖和糖尿病有关的全身能量平衡中的重要性，现在已经在实验模型中得到了科学的证实，就像棕色脂肪在成年人中的存在一样。因此，确定控制棕色和米色脂肪的形成及其生理功能的途径是至关重要的。改进棕色脂肪的成像将是评估人类生物学的关键，开发治疗方法将导致临床试验是至关重要的。因此，本次Keystone研讨会的目标是将学术界、生物技术和大型制药行业的顶级专家聚集在一起，研究控制棕色脂肪发育和产热的新途径。在这方面，与会者将深入研究棕色脂肪细胞的类型，米色，经典棕色和其他。组织者特别强调了新兴的方法，包括生物和化学方法，可以将这些细胞用于治疗目的。因此，预计这次会议将促进学术界和制药界探索这一前景广阔的研究领域的更大努力。这次会议还将使学生和研究员接触到可用的问题和潜在的解决方案。

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Beige and Brown Fat: Basic Biology and Novel Therapeutics, organized by Bruce M. Spiegelman and Sven Enerback. The meeting will be held in Snowbird, Utah from April 17-22, 2015. The epidemic of obesity and diabetes has become a world-wide health risk and these metabolic disorders are a direct threat to the health and economic well-being of many nations. Unfortunately, education about diet and exercise are not sufficient to meet this emergency and new therapies are badly needed. Brown fat has emerged as one of the few genuinely new approaches to these problems. Brown fat exists in most or all adult humans and can dissipate caloric energy and attenuate both obesity and diabetes in experimental animals. The importance of brown fat (in all of its types) in whole body energy balance relating to obesity and diabetes is now settled science in experimental models, as is the existence of brown fat in adult humans. It is therefore critical to identify the pathways that control both the formation of brown and beige fats as well as their physiological function. Improved imaging in brown fat will be critical for assessment of human biology and the development of therapeutic approaches that will lead to clinical trials is of utmost importance. Therefore, the goal of this Keystone Symposia meeting is to bring together top experts from academia, biotech and large Pharma to address new pathways controlling brown fat development and thermogenesis. In this regard, attendees will delve into the types of brown fat cells, beige, classical brown and others. The organizers have placed special emphasis on emerging approaches, both biological and chemical, that can manipulate these cells for therapeutic purposes. Therefore, it is anticipated that this meeting will nucleate expanded efforts in both academia and pharma to explore this promising research area. This meeting will also expose students and fellows to the problems and potential solutions that are available.