Center for Molecular Epidemiology

分子流行病学中心

• 批准号: 9234559
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 221.63万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9234559
• 关键词: Achievement; Address; Advisory Committees; Arts; Basic Science; Biology; Biomedical Research; Centers of Research Excellence; Chemoprevention; Clinical; Complement; Department chair; Development; Disease; Disease Pathway; Emerging Technologies; Ensure; Epidemiologist; Epidemiology; Epigenetic Process; Etiology; Evaluation; Faculty; Faculty Recruitment; Fostering; Funding; Future; Genetic; Goals; Grant; Health; Human; Immunology; International; Investigation; Lead; Longevity; Maine; Malignant Neoplasms; Measures; Medical center; Mentors; Mentorship; Metagenomics; Methodology; Methods; Molecular; Molecular Epidemiology; Monitor; New England; New Hampshire; Norris Cotton Cancer Center; Outcome; Pathogenesis; Pharmacology and Toxicology; Physicians; Population Study; Positioning Attribute; Prevention; Principal Investigator; Public Health; Recording of previous events; Recruitment Activity; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Science; Scientist; Senior Scientist; Statistical Computing; Structure; Talents; Technology; Time; Trace Elements; Translating; Translations; United States National Institutes of Health; Vermont; biobank; bioimaging; burden of illness; career; career development; college; epidemiology study; experience; human disease; improved; innovation; interest; medical schools; member; multidisciplinary; next generation; prevent; programs; public health relevance; research and development; tenure track

DESCRIPTION (provided by applicant): We proposed to establish a sustainable Center of Biomedical Research Excellence (COBRE) in Molecular Epidemiology at Dartmouth structured to support the recruitment, career development, and engagement of talented junior investigators who will advance their research in molecular epidemiology as part of the new Center. We will bring together a diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns, and ultimately inform clinical decision and practice change. Faculty will span multiple departments in Dartmouth Medical School, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. Dartmouth Medical School has a long and distinguished tradition in epidemiology having conducted the first NIH funded chemoprevention trial of cancer in the early 1980s, and numerous population based studies to illuminate the pathogenesis of major health outcomes. Extending this tradition with strong support from Dartmouth will position us to serve as a vital resource in molecular epidemiology for northern New England and for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs nationally. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along with a state-of-the-art, multidisciplinary Biorepository Core and vibrant Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to establish this new Center over the next five years with the goals of: 1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan.

描述（由申请人提供）：我们建议在达特茅斯建立一个可持续的分子流行病学生物医学研究卓越中心（COBRE），其结构旨在支持招聘，职业发展和有才华的初级研究人员的参与，这些研究人员将作为新中心的一部分推进分子流行病学研究。我们将汇集一个多元化的教师，他们在整合和翻译尖端科学技术和发现方面有着共同的兴趣，以提高我们对主要人类健康问题的理解，并最终为临床决策和实践变革提供信息。教师将跨越多个部门在达特茅斯医学院，达特茅斯希区柯克医疗中心，和达特茅斯艺术和科学学院。达特茅斯医学院在流行病学方面有着悠久而杰出的传统，在20世纪80年代初进行了第一次NIH资助的癌症化学预防试验，并进行了许多基于人群的研究，以阐明主要健康结果的发病机制。在达特茅斯的大力支持下扩展这一传统，将使我们成为北方新英格兰和全国COBRE和IDEA生物医学研究卓越网络（INBRE）项目的重要分子流行病学资源。据我们所知，在新英格兰没有其他的分子流行病学学术中心，也没有目前资助的全国性分子流行病学COBREs。作为拟议的COBRE的一部分，我们将提供关键的分子流行病学研究基础设施，从中可以应用创新方法，并可以转化新发现。这将通过四个独立的研究项目来实现，这些项目的主题沿着着最先进的多学科生物储备核心和充满活力的行政，职业发展和研究整合核心。在新罕布什尔州分子流行病学不断发展的基础上，我们准备在未来五年内建立这个新的中心，目标是：1）激励严格的创新研究，促进初级研究人员的职业发展，并招募新的教师，2）促进新兴技术和疾病病因学和进展的共同途径的基础研究成果的翻译，以及3）告知在整个生命周期中预防人类疾病的策略。