Center for Molecular Epidemiology

描述(由申请人提供)：我们建议在达特茅斯建立一个可持续发展的分子流行病学生物医学研究卓越中心(COBRE)，旨在支持有才华的初级研究人员的招聘、职业发展和聘用，作为新中心的一部分，他们将推进他们在分子流行病学方面的研究。我们将汇集不同的教职员工，他们在整合和转化尖端科学技术和发现方面有着共同的兴趣，以提高我们对主要人类健康问题的理解，并最终为临床决策和实践变革提供信息。教师将跨越达特茅斯医学院、达特茅斯希区柯克医学中心和达特茅斯艺术与科学学院的多个系。达特茅斯医学院在流行病学方面有着悠久而杰出的传统，在20世纪80年代初进行了由美国国立卫生研究院资助的第一项癌症化学预防试验，并进行了大量基于人群的研究，以阐明主要健康后果的发病机制。在达特茅斯的大力支持下延续这一传统，将使我们成为新英格兰北部的分子流行病学以及全国Cobre和IDEA生物医学研究卓越网络(INBRE)计划的重要资源。据我们所知，在新英格兰没有其他分子流行病学的学术中心，也没有其他国家资助的专注于分子流行病学的Cobres。作为拟议的Cobre的一部分，我们将提供关键的分子流行病学研究基础设施，从中可以应用创新方法并转化新发现。这将通过四个主题紧密交织的独立研究项目以及一个最先进的、多学科的生物库核心和充满活力的行政、职业发展和研究集成核心来实现。在分子流行病学在新罕布夏州不断发展的基础上，我们准备在未来五年内建立这个新的中心，目标是：1)刺激严格的创新研究，促进初级研究人员的职业发展和招聘新教师；2)促进新兴技术和基础研究成果在疾病病因和进展的常见途径上的翻译；3)为预防人类终身疾病的战略提供信息。

DESCRIPTION (provided by applicant): We proposed to establish a sustainable Center of Biomedical Research Excellence (COBRE) in Molecular Epidemiology at Dartmouth structured to support the recruitment, career development, and engagement of talented junior investigators who will advance their research in molecular epidemiology as part of the new Center. We will bring together a diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns, and ultimately inform clinical decision and practice change. Faculty will span multiple departments in Dartmouth Medical School, Dartmouth Hitchcock Medical Center, and the Dartmouth College of Arts and Sciences. Dartmouth Medical School has a long and distinguished tradition in epidemiology having conducted the first NIH funded chemoprevention trial of cancer in the early 1980s, and numerous population based studies to illuminate the pathogenesis of major health outcomes. Extending this tradition with strong support from Dartmouth will position us to serve as a vital resource in molecular epidemiology for northern New England and for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs nationally. To our knowledge, there are no other academic centers for molecular epidemiology in New England, or currently funded COBREs focused on molecular epidemiology nationally. As part of the proposed COBRE, we will supply the critical molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. This will be achieved through four independent research projects with tightly interwoven themes along with a state-of-the-art, multidisciplinary Biorepository Core and vibrant Administrative, Career Development, and Research Integration Core. Building on the growing presence of molecular epidemiology in New Hampshire, we are poised to establish this new Center over the next five years with the goals of: 1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty, 2) promoting translation of emerging technologies and basic research findings on common pathways of disease etiology and progression, and 3) informing strategies to prevent human disease throughout the lifespan.