Center for Molecular Epidemiology

总体摘要 建立分子流行病学中心，生物医学研究卓越中心（COBRE）， 在达特茅斯进行分子流行病学领域的研究。作为唯一的分子中心 流行病学在北方新英格兰，和全国唯一的COBRE计划之一，这一重点，我们 已经成功地招募和指导了早期职业调查员，他们现在正在成为独立的， 他们的事业他们代表了这一新兴研究领域的新一代研究人员， 区域和国家。在这样做的过程中，我们扩大了我们的研究生产力和赠款组合， 越来越多的出版物和赠款证明了这一点。除了他们的独立赠款外， 提交，我们紧密的研究小组催化了一些重大举措和跨学科 通过利用中心资源来提供机会。这些成就包括建立一个 流行病学，增加计划和中心奖励支持，并实现创新的跨学科 培训赠款。作为第二阶段申请的一部分，我们建议将我们的中心推向可持续发展 进一步加强有才能的初级调查员的征聘、职业发展和参与。我们 我将把这个不断扩大的多元化教师群体聚集在一起，他们在整合和翻译方面有着共同的兴趣 尖端的科学技术和发现，以提高我们对人类健康的主要认识 性问题这些努力对于指导临床决策、公共卫生政策和实践变革至关重要。 我们将加强我们充满活力的分子流行病学研究基础设施， 可以应用，新的发现可以被翻译。具体来说，我们将增加四个独立的 研究项目与交织的主题是由我们的国家的最先进的生物储备核心支持创建 在第一阶段通过我们有效的行政，职业发展和研究整合核心，我们将 提供试点计划，以激励开拓性研究和区域合作伙伴关系。这些基本 这些组成部分将使我们能够实现以下目标：（1）激励严格的创新研究， 初级研究人员的职业发展和招聘新的教师和成员到我们的中心，（2） 促进新技术和关于常见疾病途径的基础研究成果的转化 病因和进展，和（3）告知策略，以防止人类疾病的整个生命周期。我们 第一阶段的成功，加上强有力的机构支持，使我们成为一个重要的资源， 北方新英格兰分子流行病学、COBRE和IDEA生物医学研究网络 卓越（INBRE）计划区域和国家，并培养更广泛的分子流行病学。

OVERALL ABSTRACT Establishing the Center for Molecular Epidemiology, Center for Biomedical Research Excellence (COBRE) has transformed research in the field of molecular epidemiology at Dartmouth. As the only Center for Molecular Epidemiology in northern New England, and one of the only COBRE programs nationally with this focus, we have successfully recruited and mentored early career investigators who are now becoming independent in their careers. They represent the new generation of investigators in this emerging area of research both regionally and nationally. In doing so, we have expanded our research productivity and grant portfolio, as evidenced by a growing number of publications and grants awarded. In addition to their independent grant submissions, our tight-knit group of investigators catalyzed a number of major initiatives and interdisciplinary grant opportunities by leveraging Center resources. These achievements include creating a Department of Epidemiology, increasing program and center award support, and attaining innovative cross-disciplinary training grants. As part of this Phase II application, we proposed to progress our Center towards sustainability by further enhancing recruitment, career development, and engagement of talented junior investigators. We will bring together this enlarging group of diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns. Such efforts are crucial for directing clinical decisions, public health policies and practice change. We will strengthen our vibrant molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. Specifically, we will add four new independent research projects with intertwined themes that are supported by our state-of-the-art Biorepository Core created in Phase I. Through our effective Administrative, Career Development, and Research Integration Core, we will offer a Pilot Program to incentivize pioneering research and regional partnerships. These essential components will allow us to achieve our goals of: (1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty and members to our Center, (2) promoting translation of novel technologies and basic research findings on common pathways of disease etiology and progression, and (3) informing strategies to prevent human disease throughout the lifespan. Our success in Phase I combined with strong institutional support, positions us to serve as a vital resource in molecular epidemiology for northern New England, COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs regional and nationally, and for cultivating molecular epidemiology more broadly.