Center for Molecular Epidemiology

总体摘要 建立分子流行病学中心，生物医学研究卓越中心(COBRE) 达特茅斯大学分子流行病学领域的转化研究。作为唯一的分子研究中心 新英格兰北部的流行病学，以及全国仅有的关注这一点的Cobre项目之一，我们 已经成功招聘并指导了早期职业调查人员，他们现在正在成为独立的 他们的事业。他们代表了这一新兴研究领域的新一代研究人员 在地区和全国范围内。通过这样做，我们扩大了研究效率和拨款组合，如 越来越多的出版物和授予的赠款证明了这一点。除了他们的独立赠款 提交材料，我们紧密联系的调查小组催化了许多重大倡议和跨学科 通过利用中心资源授予机会。这些成就包括创建一个 流行病学，增加项目和中心奖励支持，实现创新的跨学科 培训补助金。作为第二阶段申请的一部分，我们建议将我们的中心向可持续发展方向发展 通过进一步加强招聘、职业发展和有才华的初级调查人员的参与。我们 将把这个不断扩大的不同教职员工群体聚集在一起，他们在整合和翻译方面有着共同的兴趣 尖端科学技术和发现提高我们对主要人类健康的理解 担忧。这些努力对于指导临床决策、公共卫生政策和实践变革至关重要。 我们将加强我们充满活力的分子流行病学研究基础设施，创新方法 可以应用，也可以转化为新的发现。具体来说，我们将添加四个新的独立 由我们创建的最先进的生物信息库核心支持的相互交织的主题的研究项目 在第一阶段，通过我们有效的行政、职业发展和研究集成核心，我们将 提供一个试点计划，以激励开创性研究和区域合作伙伴关系。这些是必不可少的 组件将使我们能够实现我们的目标：(1)激励严谨的创新研究和促进 初级调查员的职业发展和中心新教职员工的招聘，(2) 促进常见疾病途径的新技术和基础研究成果的翻译 病因和进展，以及(3)提供在整个生命周期内预防人类疾病的战略。我们的 第一阶段的成功与强有力的机构支持相结合，使我们能够成为 新英格兰北部、科布雷和IDEA生物医学研究网络的分子流行病学 卓越(INBRE)计划在区域和国家范围内，培养更广泛的分子流行病学。

OVERALL ABSTRACT Establishing the Center for Molecular Epidemiology, Center for Biomedical Research Excellence (COBRE) has transformed research in the field of molecular epidemiology at Dartmouth. As the only Center for Molecular Epidemiology in northern New England, and one of the only COBRE programs nationally with this focus, we have successfully recruited and mentored early career investigators who are now becoming independent in their careers. They represent the new generation of investigators in this emerging area of research both regionally and nationally. In doing so, we have expanded our research productivity and grant portfolio, as evidenced by a growing number of publications and grants awarded. In addition to their independent grant submissions, our tight-knit group of investigators catalyzed a number of major initiatives and interdisciplinary grant opportunities by leveraging Center resources. These achievements include creating a Department of Epidemiology, increasing program and center award support, and attaining innovative cross-disciplinary training grants. As part of this Phase II application, we proposed to progress our Center towards sustainability by further enhancing recruitment, career development, and engagement of talented junior investigators. We will bring together this enlarging group of diverse faculty with shared interests in integrating and translating cutting edge scientific technologies and discoveries to improve our understanding of major human health concerns. Such efforts are crucial for directing clinical decisions, public health policies and practice change. We will strengthen our vibrant molecular epidemiology research infrastructure from which innovative methods can be applied and new discoveries can be translated. Specifically, we will add four new independent research projects with intertwined themes that are supported by our state-of-the-art Biorepository Core created in Phase I. Through our effective Administrative, Career Development, and Research Integration Core, we will offer a Pilot Program to incentivize pioneering research and regional partnerships. These essential components will allow us to achieve our goals of: (1) stimulating rigorous innovative research and fostering the career development of junior investigators and recruiting new faculty and members to our Center, (2) promoting translation of novel technologies and basic research findings on common pathways of disease etiology and progression, and (3) informing strategies to prevent human disease throughout the lifespan. Our success in Phase I combined with strong institutional support, positions us to serve as a vital resource in molecular epidemiology for northern New England, COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs regional and nationally, and for cultivating molecular epidemiology more broadly.