Gene Expression Profiling and Clinical Characterization of Phototoxicity

光毒性的基因表达谱和临床特征

• 批准号: 9556404
• 负责人: Heidi Kong
• 金额: $ 1.19万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9556404
• 关键词: Biopsy; Clinical; Cutaneous; Cytochrome P450; Diuretics; Doxycycline; Gene Expression; Gene Expression Profiling; Genotype; Goals; Human Resources; Investigation; Light; Microarray Analysis; Non-Steroidal Anti-Inflammatory Agents; Pathway interactions; Pharmaceutical Preparations; Phototoxicity; Protocols documentation; Reaction; Recommendation; Role; Sampling; Serum; Skin; Staining method; Stains; Sunscreening Agents; Testing; UV Radiation Exposure; Ultraviolet Rays; Visible Radiation; Voriconazole; antimicrobial; healthy volunteer; response; translational approach; ultraviolet

In 2010, the protocol was amended to allow us to treat a subset of returning healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of the additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of the additional biopsies obtained from healthy volunteers treated with doxycycline. In fiscal year 2013, we investigated the serum levels of doxycycline from the healthy volunteers who participated in the study in previous years. Due to insufficient personnel, additional analyses were held. In fiscal year 2017, the protocol was amended to allow additional investigation of skin samples post-UV exposure.

2010 年，该方案进行了修订，允许我们使用多西环素治疗一部分返回的健康志愿者，以获得更多的活检结果。 2011年，我们完成了对额外健康志愿者的治疗。 2012 年，我们完成了对接受多西环素治疗的健康志愿者获得的额外活检样本的免疫组织化学染色分析。 2013财年，我们调查了前几年参与该研究的健康志愿者的血清强力霉素水平。由于人员不足，进行了额外的分析。 2017 财年，该协议进行了修订，允许对紫外线照射后的皮肤样本进行额外调查。