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Gene Expression Profiling and Clinical Characterization of Phototoxicity

Gene Expression Profiling and Clinical Characterization of Phototoxicity
光毒性的基因表达谱和临床特征
批准号：
9556404
负责人：
Heidi Kong
金额：
$1.19万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9556404
关键词：
BiopsyClinicalCutaneousCytochrome P450DiureticsDoxycyclineGene ExpressionGene Expression ProfilingGenotypeGoalsHuman ResourcesInvestigationLightMicroarray AnalysisNon-Steroidal Anti-Inflammatory AgentsPathway interactionsPharmaceutical PreparationsPhototoxicityProtocols documentationReactionRecommendationRoleSamplingSerumSkinStaining methodStainsSunscreening AgentsTestingUV Radiation ExposureUltraviolet RaysVisible RadiationVoriconazoleantimicrobialhealthy volunteerresponsetranslational approachultraviolet

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中文摘要
翻译
2010年，该方案进行了修订，允许我们用强力霉素治疗一部分返回的健康志愿者，以获得额外的活检。2011年，我们完成了额外健康志愿者的治疗。2012年，我们完成了对接受多西环素治疗的健康志愿者的额外活检组织的免疫组织化学染色分析。在2013财政年度，我们调查了前几年参与研究的健康志愿者的多西环素血清水平。由于人员不足，进行了额外的分析。在2017财年，对方案进行了修订，以允许对紫外线暴露后的皮肤样本进行额外研究。
英文摘要
In 2010, the protocol was amended to allow us to treat a subset of returning healthy volunteers with doxycycline to obtain additional biopsies. In 2011, we completed treatment of the additional healthy volunteers. In 2012, we completed the analysis of immunohistochemical staining of the additional biopsies obtained from healthy volunteers treated with doxycycline. In fiscal year 2013, we investigated the serum levels of doxycycline from the healthy volunteers who participated in the study in previous years. Due to insufficient personnel, additional analyses were held. In fiscal year 2017, the protocol was amended to allow additional investigation of skin samples post-UV exposure.
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Effects of systemic and topical perturbations on human microbes
Botulinum Toxin for Painful Cutaneous Leiomyomas
Gene Expression Profiling and Clinical Characterization of Phototoxicity
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
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