小血管脑血管疾病的新型成像和内皮生物标志物-猫眼课题宝

小血管脑血管疾病的新型成像和内皮生物标志物

批准号：

9543065

负责人：

Charles DeCarli

金额：

$118.29万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-09-30 至 2021-07-31

来源：

https://reporter.nih.gov/project-details/9543065

关键词：

Address Age Alzheimer&apos s Disease Amyloid Anisotropy Biological Markers Blood Blood - brain barrier anatomy Brain CXCL5 gene CXCL6 gene Cerebrovascular Disorders Cerebrum Clinical Trials Cognition Collection Communities Comorbidity DNA Data Dementia Diagnosis Diffusion Magnetic Resonance Imaging Disease Early Diagnosis Elderly Endothelial Cells Family Functional disorder Goals IGFBP2 gene ITGB3 gene Image Impaired cognition Inflammatory Injury Integrins Lesion Longitudinal Studies Magnetic Resonance Imaging Measures Methods Microscopic Microvascular Dysfunction Modality Modeling Multimodal Imaging Outcome Pathology Permeability Phase Phenotype Plasma Positron-Emission Tomography Process Serological Serum Signal Transduction Site Stroke Structure Testing Time Vascular Diseases Water Work base blood-based biomarker candidate marker cerebral amyloidosis cerebrovascular chemokine clinical research site cognitive ability cognitive testing cohort cytokine endothelial dysfunction executive function follow-up functional decline functional disability improved magnetic resonance imaging biomarker member mild cognitive impairment neuroimaging novel outcome forecast potential biomarker processing speed receptor standard measure validation studies white matter white matter injury

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Project Summary /Abstract Small vessel cerebrovascular disease and Alzheimer's disease are the two most common causes of cognitive decline in the elderly, but methods for determining the relative contributions of both these pathologies to functional impairment, understanding their interactions, predicting progression and defining targets for clinical trials remain underdeveloped. The overarching goal of this proposal is to further develop novel neuroimaging and serologic biomarkers of cerebrovascular disease. Accomplishing this goal will improve early detection, diagnosis, and prognosis of small vessel cerebrovascular disease in older subjects, and provide better targets and outcome metrics for clinical trials. We propose to longitudinally study 400 well characterized older subjects from ongoing projects at UCSF and UCD who present with a range of cerebrovascular burden and functional decline. Our search for biomarkers will focus on novel neuroimaging variables and measures of endothelial dysfunction. Our aims will address the relationships between these markers and measures of amyloid burden, cognition, and change over time.

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