Higher-Order Chromatin Architecture in Time and Space

时间和空间中的高阶染色质结构

• 批准号: 9910926
• 负责人: Thale Cross Jarvis
• 金额: $ 2.34万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-21 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910926
• 关键词: 3-Dimensional; Architecture; Area; Bioinformatics; Biological; Biology; British Columbia; Cell Cycle; Cell physiology; Cells; Chromatin; Collaborations; Computing Methodologies; Data; Development; Discipline; Disease; Educational workshop; Engineering; Future; Genetic; Genetic Recombination; Genetic Transcription; Genome; Genome Mappings; Goals; Imaging Device; Imaging technology; Knowledge; Learning; Maintenance; Maps; Methodology; Molecular Biology; Occupations; Outcome; Pattern; Physics; Research; Research Personnel; Resources; Role; Scientist; Structure; Students; Technology; Time; Training; Work; body system; clinical practice; computer science; computerized tools; data resource; frontier; genome analysis; genome-wide; human disease; interest; mammalian genome; mathematical sciences; next generation; novel; posters; programs; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Higher Order Chromatin Architecture in Time and Space, organized by Drs. Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas. The conference will be held in Whistler, British Columbia from March 15-19, 2020. Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program includes workshops with topics on leading computational methods to identify biologically relevant patterns in Hi-C data, new genome mapping and imaging technologies, and new data resources available through the 4D Nucleome consortium. Finally, the program concludes with a session devoted to novel tools for imaging and engineering the 3D genome. This Keystone Symposia conference aims to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.

抽象的 请求支持Keystone研讨会会议，标题为“高级染色质体系结构” 时间和空间，由Drs组织。 Jennifer E. Phillips-Cremins，Job Dekker和Stavros Lomvardas。这 会议将于2020年3月15日至19日在不列颠哥伦比亚省的惠斯勒举行。 哺乳动物的基因组在隔室，拓扑关联域（TADS）的层次结构中折叠， 子tad和循环相互作用。随着全基因组染色质结构图变得广泛可用， 该领域正在将重点从映射转变为理解此类结构的发展动力学， 细胞周期，并在单个细胞中短时间尺度。一个关键的新兴目标将是揭示原因和 基因组折叠与诸如转录，复制，重组和功能之间的效果关系 稳定/维护。还需要评估管理染色质的组织原理 在许多生物条件和遗传扰动中拓扑。而且，3D基因组的作用 在广泛的人类疾病状态的发作和进展中折叠和进展错误仍然很高 多个学科和器官系统的兴趣。会议计划包括与 领先的计算方法的主题，以识别HI-C数据中的生物学相关模式，新基因组 映射和成像技术以及通过4D核心联盟提供的新数据资源。 最后，该计划以专门用于成像和工程3D成像和工程的新工具结束 基因组。这次Keystone研讨会会议旨在突出跨学科的新边界，以应对 3D基因组在跨时间和空间中的细胞函数中的动力和功能作用 和疾病。