Higher-Order Chromatin Architecture in Time and Space

时间和空间中的高阶染色质结构

• 批准号: 9910926
• 负责人: Thale Cross Jarvis
• 金额: $ 2.34万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-21 至 2021-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910926
• 关键词: 3-Dimensional; Architecture; Area; Bioinformatics; Biological; Biology; British Columbia; Cell Cycle; Cell physiology; Cells; Chromatin; Collaborations; Computing Methodologies; Data; Development; Discipline; Disease; Educational workshop; Engineering; Future; Genetic; Genetic Recombination; Genetic Transcription; Genome; Genome Mappings; Goals; Imaging Device; Imaging technology; Knowledge; Learning; Maintenance; Maps; Methodology; Molecular Biology; Occupations; Outcome; Pattern; Physics; Research; Research Personnel; Resources; Role; Scientist; Structure; Students; Technology; Time; Training; Work; body system; clinical practice; computer science; computerized tools; data resource; frontier; genome analysis; genome-wide; human disease; interest; mammalian genome; mathematical sciences; next generation; novel; posters; programs; symposium

ABSTRACT Support is requested for a Keystone Symposia conference entitled Higher Order Chromatin Architecture in Time and Space, organized by Drs. Jennifer E. Phillips-Cremins, Job Dekker and Stavros Lomvardas. The conference will be held in Whistler, British Columbia from March 15-19, 2020. Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program includes workshops with topics on leading computational methods to identify biologically relevant patterns in Hi-C data, new genome mapping and imaging technologies, and new data resources available through the 4D Nucleome consortium. Finally, the program concludes with a session devoted to novel tools for imaging and engineering the 3D genome. This Keystone Symposia conference aims to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.

抽象的 请求支持题为“高阶染色质架构”的 Keystone 研讨会 时间和空间，由博士组织。 Jennifer E. Phillips-Cremins、Job Dekker 和 Stavros Lomvardas。这 会议将于2020年3月15日至19日在不列颠哥伦比亚省惠斯勒举行。 哺乳动物基因组折叠在隔室层次结构中，拓扑关联域（TAD）， subTAD 和循环交互。随着全基因组染色质结构图的广泛应用， 该领域正在将重点从绘制地图转向了解此类结构在发展中的动态， 细胞周期，以及单细胞的短时间尺度。一个重要的新兴目标将是查明原因并 基因组折叠与转录、复制、重组等功能之间的影响关系 稳定性/维护。还非常需要评估控制染色质的组织原则 跨许多生物条件和遗传扰动的拓扑。此外，3D 基因组的作用 错误折叠在多种人类疾病状态的发生和进展中仍然是一个高度关注的领域 跨多个学科和器官系统的兴趣。会议计划包括研讨会 关于识别 Hi-C 数据中生物学相关模式的领先计算方法、新基因组的主题 绘图和成像技术，以及通过 4D Nucleome 联盟提供的新数据资源。 最后，该计划以专门讨论用于 3D 成像和工程设计的新颖工具的会议结束。 基因组。这次 Keystone 研讨会旨在强调跨学科在解决问题方面的新领域 3D 基因组在发育过程中跨越时间和空间的细胞功能的动力学和功能作用 和疾病。