Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases

通过脂质激酶和磷酸酶的协调作用调节动态细胞间粘附

• 批准号: nhmrc : 455824
• 负责人: Prof Alpha Yap
• 金额: $ 35.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-dynamic-cell-kinases-phosphatases/95956
• 关键词: Regulation; dynamic; cell; adhesions; coordinated

This research project studies the molecular mechanisms that allow cells to attach to, and recognize, one another. Such cell-to-cell adhesion is mediated by the cadherin family of molecules, which reside on the surfaces of cells. Cadherins allow cells to recognize one another and, upon recognition, to adhere to each other. By this means, populations of individual cells can be linked together into cohesive populations - i.e. the tissues and organs of the body. The importance of cadherin adhesion is exemplified by the fact that disruption of cadherin adhesion contributes to many important diseases, especially inflammation and cancer. Thus understanding how cadherins hold cells together is necessary for us to understand the molecular basis of common diseases. In this project we study how cadherins signal to regulate cellular behaviour. We build on our recent discovery that E-cadherin can activate a lipid in the cell membrane, PIP3, that is known to be a key regulator of many cellular activities. We aim to understand how this signal is generated in response to E-cadherin adhesion and how it elicits normal cellular responses to cadherin adhesion.

该研究项目研究细胞相互附着和识别的分子机制。这种细胞间粘附是由位于细胞表面的钙粘蛋白家族分子介导的。钙粘蛋白使细胞能够相互识别，并在识别后相互粘附。通过这种方式，单个细胞群可以连接在一起形成有凝聚力的群体——即身体的组织和器官。钙粘蛋白粘附的重要性可以通过以下事实得到例证：钙粘蛋白粘附的破坏导致许多重要的疾病，特别是炎症和癌症。因此，了解钙粘蛋白如何将细胞结合在一起对于我们了解常见疾病的分子基础是必要的。在这个项目中，我们研究钙粘蛋白如何发出信号来调节细胞行为。我们基于最近的发现，即 E-钙粘蛋白可以激活细胞膜中的脂质 PIP3，众所周知，PIP3 是许多细胞活动的关键调节因子。我们的目的是了解该信号是如何响应 E-钙粘蛋白粘附而产生的，以及它如何引发对钙粘蛋白粘附的正常细胞反应。