Forces in Nature: Tissue mechanics and cell sociology

自然力量：组织力学和细胞社会学

• 批准号: FL230100100
• 负责人: Prof Alpha Yap
• 金额: $ 226.26万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2028-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL230100100
• 关键词: Forces; Nature; Tissue; mechanics; cell

Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery.

上皮细胞覆盖在身体的表面，形成一层屏障，保护我们免受环境的影响。尽管它们很重要，但我们对细胞如何交流知之甚少。该项目旨在利用细胞和生物物理实验与物理理论的创新组合，测试上皮细胞通过机械力的传递和检测进行通信的新概念。预期的结果是新的知识、对年轻科学家的跨学科培训、新的国家研究能力和日益增长的国际合作。好处包括加强澳大利亚的科学联系和研究能力，并提供可能导致未来在生物工程和药物发现方面取得进展的基础知识。