Forces in Nature: Tissue mechanics and cell sociology

自然力量：组织力学和细胞社会学

• 批准号: FL230100100
• 负责人: Prof Alpha Yap
• 金额: $ 226.26万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2028-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL230100100
• 关键词: Forces; Nature; Tissue; mechanics; cell

Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery.

上皮细胞覆盖体内的表面，形成盾牌以保护我们免受环境的侵害。尽管它们的重要性，但我们对细胞的沟通方式了解很差。该项目旨在测试上皮细胞通过机械力传播和检测的新颖概念，该概念是使用细胞和生物物理实验和物理理论的创新组合。预期的结果是新知识，对年轻科学家的跨学科培训，新的国家研究能力以及不断发展的国际合作。好处包括增强澳大利亚的科学联系和研究能力，并提供基本知识，这可能会导致生物工程和药物发现的未来进步。