Cadherin Biology in Morphogenesis and Disease

形态发生和疾病中的钙粘蛋白生物学

• 批准号: nhmrc : 1044041
• 负责人: Prof Alpha Yap
• 金额: $ 50.13万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cadherin-biology-morphogenesis-disease/111626
• 关键词: Cadherin; Biology; Morphogenesis; Disease

This work will analyse how cells, the building blocks of tissues, are organized together to form functioning organs. It focuses on the adhesion molecules that allow cells to recognize one another, which cooperate with the internal skeleton of cells to link them together. We aim to understand how these cellular systems work normally and how they are targeted to disrupt tissue integrity in diseases like cancer and inflammation.

这项工作将分析细胞是如何组织在一起形成功能器官的。它专注于让细胞相互识别的黏附分子，这些黏附分子与细胞的内部骨架合作，将它们连接在一起。我们的目标是了解这些细胞系统是如何正常工作的，以及它们是如何针对癌症和炎症等疾病破坏组织完整性的。