Mechanobiology of epithelial homeostasis in health and disease

健康和疾病中上皮稳态的力学生物学

• 批准号: nhmrc : 1136592
• 负责人: Prof Alpha Yap
• 金额: $ 59.23万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanobiology-epithelial-homeostasis-health-disease/1318477
• 关键词: Mechanobiology; epithelial; homeostasis; health; disease

Epithelial tissues, such as the lung, fundamentally protect the body from its external environment. For this, they must detect and respond to danger. My work has discovered a new biological system where cells monitor changes in mechanical forces as a sign of danger. Diseases such as inflammation and cancer occur when this detection system fails. This Fellowship builds on my lab’s pioneering work to understand how force is used to sense danger, and how disease occurs when it goes awry.

上皮组织，如肺，从根本上保护身体免受外部环境的影响。为此，他们必须发现并应对危险。我的工作发现了一种新的生物系统，细胞监测机械力的变化，作为危险的信号。当这种检测系统失效时，就会发生炎症和癌症等疾病。这个奖学金建立在我的实验室的开创性工作，以了解如何使用武力来感知危险，以及疾病是如何发生的，当它出错。