Tissue tension homeostasis by junctional mechanosensing.
Tissue tension homeostasis by junctional mechanosensing.
批准号:
DP150101367
负责人:
Prof Alpha Yap
金额:
$31.22万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
This project examines how tissues use mechanical tension to preserve their integrity. This comes from the recent appreciation that cells pull on the connections between each other to generate tension. Further, molecular mechanisms exist for cells to sense changes in this tension and then to enlist the appropriate responses to restore tension. The project aims to test how local changes in tension are detected and corrected, when tissue integrity is compromised by very different causes. The project endeavours to establish a new conceptual paradigm for understanding tissue homeostasis, based on cell biology and biomechanics, with implications for developmental biology and tissue engineering.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Forces in Nature: Tissue mechanics and cell sociology
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批准号:FL230100100
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项目类别:Australian Laureate Fellowships
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资助金额:$226.26万
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财政年份:2024
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负责人:Prof Alpha Yap
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依托单位:
Keeping forces local for epithelial homeostasis
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批准号:DP220103951
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项目类别:Discovery Projects
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资助金额:$41.1万
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财政年份:2022
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负责人:Prof Alpha Yap
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依托单位:
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
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批准号:DP190102871
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项目类别:Discovery Projects
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资助金额:$52.78万
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财政年份:2019
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负责人:Prof Alpha Yap
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依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
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批准号:nhmrc : 1140090
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项目类别:Project Grants
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资助金额:$73.78万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
Mechanobiology of epithelial homeostasis in health and disease
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批准号:nhmrc : GNT1136592
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项目类别:Research Fellowships
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资助金额:$87.6万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
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批准号:nhmrc : GNT1140090
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项目类别:Project Grants
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资助金额:$109.12万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
Mechanobiology of epithelial homeostasis in health and disease
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批准号:nhmrc : 1136592
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项目类别:Research Fellowships
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资助金额:$59.23万
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财政年份:2018
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负责人:Prof Alpha Yap
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依托单位:
A mechanotransduction apparatus to coordinate epithelial collective cell migration.
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批准号:nhmrc : 1123816
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项目类别:Project Grants
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资助金额:$67.95万
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财政年份:2017
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负责人:Prof Alpha Yap
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依托单位:
Cadherin Biology in Morphogenesis and Disease
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批准号:nhmrc : 1044041
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项目类别:Research Fellowships
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资助金额:$50.13万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
The Plasma membrane in health and disease
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批准号:nhmrc : GNT1037320
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项目类别:Programs
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资助金额:$473.47万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Program in Membrane Interface Biology
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批准号:nhmrc : 1037320
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项目类别:Program Grants
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资助金额:$498.05万
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财政年份:2013
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负责人:Prof Alpha Yap
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依托单位:
Mechanotransduction: a new paradigm for cadherin junction biology
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批准号:DP120104667
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项目类别:Discovery Projects
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资助金额:$25.78万
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财政年份:2012
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负责人:Prof Alpha Yap
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依托单位:
Cortactin: integrating cadherin signalling for junctional integrity
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批准号:nhmrc : 1010489
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项目类别:NHMRC Project Grants
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资助金额:$39.6万
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财政年份:2011
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负责人:Prof Alpha Yap
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 631383
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项目类别:NHMRC Research Fellowships
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资助金额:$25.67万
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财政年份:2010
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负责人:Prof Alpha Yap
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依托单位:
Myosin VI: a novel molecular apparatus for epithelial cohesion
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批准号:nhmrc : 631377
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项目类别:NHMRC Project Grants
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资助金额:$40.35万
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财政年份:2010
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负责人:Prof Alpha Yap
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依托单位:
Actin cytoskeleton regulation by E-cadherin and Src.
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批准号:DP0988935
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项目类别:Discovery Projects
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资助金额:$20.8万
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财政年份:2009
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负责人:Prof Alpha Yap
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依托单位:
Regulation of Myosin II by E-cadherin adhesion.
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批准号:nhmrc : 511155
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项目类别:NHMRC Project Grants
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资助金额:$38.24万
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财政年份:2008
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负责人:Prof Alpha Yap
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依托单位:
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
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批准号:nhmrc : 511156
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项目类别:NHMRC Project Grants
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资助金额:$37.2万
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财政年份:2008
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负责人:Prof Alpha Yap
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依托单位:
Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
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批准号:nhmrc : 455824
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项目类别:NHMRC Project Grants
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资助金额:$35.31万
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财政年份:2007
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负责人:Prof Alpha Yap
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依托单位:
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
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批准号:DP0664395
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项目类别:Discovery Projects
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资助金额:$17.6万
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财政年份:2006
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负责人:Prof Alpha Yap
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依托单位:
国内基金
海外基金
体外流体环境下内皮和平滑肌细胞共培养与细胞行为的研究
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批准号:32070799
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项目类别:面上项目
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资助金额:58.0万元
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批准年份:2020
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负责人:丁永胜
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依托单位: