Tissue tension homeostasis by junctional mechanosensing.

通过连接机械传感实现组织张力稳态。

• 批准号: DP150101367
• 负责人: Prof Alpha Yap
• 金额: $ 31.22万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101367
• 关键词: Tissue; tension; homeostasis; junctional; mechanosensing.

This project examines how tissues use mechanical tension to preserve their integrity. This comes from the recent appreciation that cells pull on the connections between each other to generate tension. Further, molecular mechanisms exist for cells to sense changes in this tension and then to enlist the appropriate responses to restore tension. The project aims to test how local changes in tension are detected and corrected, when tissue integrity is compromised by very different causes. The project endeavours to establish a new conceptual paradigm for understanding tissue homeostasis, based on cell biology and biomechanics, with implications for developmental biology and tissue engineering.

本项目研究组织如何利用机械张力来保持其完整性。这来自于最近的一种认识，即细胞相互之间的连接产生张力。此外，存在分子机制使细胞感知这种张力的变化，然后获得适当的反应来恢复张力。该项目旨在测试当组织完整性受到不同原因的损害时，如何检测和纠正局部张力变化。该项目致力于建立一个新的概念范式来理解组织稳态，基于细胞生物学和生物力学，与发育生物学和组织工程的影响。