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Tissue tension homeostasis by junctional mechanosensing.

Tissue tension homeostasis by junctional mechanosensing.
通过连接机械传感实现组织张力稳态。
批准号:
DP150101367
负责人:
Prof Alpha Yap
金额:
$31.22万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31

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中文摘要
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英文摘要
This project examines how tissues use mechanical tension to preserve their integrity. This comes from the recent appreciation that cells pull on the connections between each other to generate tension. Further, molecular mechanisms exist for cells to sense changes in this tension and then to enlist the appropriate responses to restore tension. The project aims to test how local changes in tension are detected and corrected, when tissue integrity is compromised by very different causes. The project endeavours to establish a new conceptual paradigm for understanding tissue homeostasis, based on cell biology and biomechanics, with implications for developmental biology and tissue engineering.
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Forces in Nature: Tissue mechanics and cell sociology
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    FL230100100
  • 项目类别:
    Australian Laureate Fellowships
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  • 财政年份:
    2024
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Keeping forces local for epithelial homeostasis
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    2022
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    Prof Alpha Yap
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RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
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    DP190102871
  • 项目类别:
    Discovery Projects
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  • 财政年份:
    2019
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How caveolae condition tissue mechanics for an anti-tumor niche.
  • 批准号:
    nhmrc : 1140090
  • 项目类别:
    Project Grants
  • 资助金额:
    $73.78万
  • 财政年份:
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  • 负责人:
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国内基金
海外基金
体外流体环境下内皮和平滑肌细胞共培养与细胞行为的研究
  • 批准号:
    32070799
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    丁永胜
  • 依托单位: