RhoA signaling: the nanoscale mechanisms of mechanochemical regulation

RhoA 信号传导：机械化学调节的纳米级机制

• 批准号: DP190102871
• 负责人: Prof Alpha Yap
• 金额: $ 52.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2023-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102871
• 关键词: RhoA; signaling; nanoscale; mechanisms; mechanochemical

This project aims to elucidate a new paradigm for regulating cell signals at the nanoscale level. Cell signalling involves the coordination of multi-molecular networks at the plasma membrane, the interface between the cell and its external environment. These are often thought to involve the assembly of multimolecular complexes through the action of protein scaffolds. This project will focus on how the contractile regulator, anillin, controls RhoA signalling by kinetic regulation. In particular, how nanoscale clustering of anillin by the dynamic actomyosin cytoskeleton modulates RhoA signalling for contractility and tissue homeostasis. The outcomes of this project are first and foremost fundamental understanding of how cells communicate with one another.

该项目旨在阐明一种在纳米级调节细胞信号的新范式。细胞信号传递涉及细胞膜上多分子网络的协调，质膜是细胞与外部环境之间的界面。这些通常被认为涉及通过蛋白质支架的作用组装多分子复合体。这个项目将集中在收缩调节剂苯丙素如何通过动力学调节来控制RhoA信号。特别是，如何通过动态的肌球蛋白细胞骨架调节RhoA信号来调节收缩和组织内稳的苯青素的纳米级聚集。这个项目的成果首先是对细胞如何相互通信的基本理解。