How caveolae condition tissue mechanics for an anti-tumor niche.

小凹如何调节组织力学以获得抗肿瘤利基。

• 批准号: nhmrc : 1140090
• 负责人: Prof Alpha Yap
• 金额: $ 73.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/caveolae-condition-tissue-tumor-niche/1319164
• 关键词: How; caveolae; condition; tissue; mechanics

The outcome of cancer is determined not only by the behaviour of the cancer cell, but also by how the normal tissue cells of the body respond to it. This project investigates how tissue cells that surround cancer cells can eliminate early cancers from the body. It develops on newly-discovered mechanisms that allow epithelial tissues to detect and physically expel cancer cells. This mechanism can protect us from cancer, but potentially allow cancer to develop when it fails.

癌症的结果不仅取决于癌细胞的行为，还取决于身体的正常组织细胞对它的反应。本项目研究癌细胞周围的组织细胞如何从身体中消除早期癌症。它基于新发现的机制，允许上皮组织检测和物理驱逐癌细胞。这种机制可以保护我们免受癌症的侵害，但当它失败时，可能会让癌症发展。