Keeping forces local for epithelial homeostasis

保持局部力量以保持上皮稳态

• 批准号: DP220103951
• 负责人: Prof Alpha Yap
• 金额: $ 41.1万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-21 至 2025-01-20
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103951
• 关键词: Keeping; forces; local; epithelial; homeostasis

This project probes how epithelial cells use mechanical forces to communicate with one another in biological life. It tests the novel concept that negative feedback is a critical, hitherto unappreciated dimension in mechanical communication, which acts to ensure proportionate responses for homeostasis. It will generate fundamental new knowledge in biology using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are fundamental new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. It will benefit Australia by enhancing its scientific world linkage, status in scientific leadership and research capacity.

该项目探讨了上皮细胞如何利用机械力在生物生命中相互沟通。它测试了一个新概念，即负反馈是机械通讯中一个关键的、迄今为止未被重视的维度，它的作用是确保体内平衡的相应反应。它将利用细胞和生物物理实验以及物理理论的创新组合产生生物学的基础新知识。预期成果是基础新知识、年轻科学家的跨学科培训、新的国家研究能力和不断增长的国际合作。它将通过增强其科学世界联系、科学领导地位和研究能力而使澳大利亚受益。