Keeping forces local for epithelial homeostasis
Keeping forces local for epithelial homeostasis
批准号:
DP220103951
负责人:
Prof Alpha Yap
金额:
$41.1万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2022
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2022-01-21 至 2025-01-20
中文摘要
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英文摘要
This project probes how epithelial cells use mechanical forces to communicate with one another in biological life. It tests the novel concept that negative feedback is a critical, hitherto unappreciated dimension in mechanical communication, which acts to ensure proportionate responses for homeostasis. It will generate fundamental new knowledge in biology using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are fundamental new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. It will benefit Australia by enhancing its scientific world linkage, status in scientific leadership and research capacity.
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会议论文
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批准号:nhmrc : GNT1136592
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The Plasma membrane in health and disease
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Uncoupled Research Fellowship
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资助金额:$25.67万
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财政年份:2010
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依托单位:
Myosin VI: a novel molecular apparatus for epithelial cohesion
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Actin cytoskeleton regulation by E-cadherin and Src.
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Regulation of Myosin II by E-cadherin adhesion.
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批准号:nhmrc : 511155
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项目类别:NHMRC Project Grants
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资助金额:$38.24万
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财政年份:2008
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依托单位:
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
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财政年份:2008
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Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
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项目类别:NHMRC Project Grants
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资助金额:$35.31万
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财政年份:2007
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依托单位:
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
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项目类别:Discovery Projects
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资助金额:$17.6万
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财政年份:2006
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负责人:Prof Alpha Yap
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依托单位:
国内基金
海外基金
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