A mechanotransduction apparatus to coordinate epithelial collective cell migration.

协调上皮集体细胞迁移的机械转导装置。

• 批准号: nhmrc : 1123816
• 负责人: Prof Alpha Yap
• 金额: $ 67.95万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanotransduction-apparatus-coordinate-cell-migration/947227
• 关键词: mechanotransduction; apparatus; coordinate; epithelial; collective

Epithelial cells migrate as physically coherent collective groups, which is necessary for normal development and is disrupted as cancers progress to become invasive and spread. Collective migration requires communication so that the behaviour of individual cells is properly coordinated. In this project we investigate how the transmission of physical force between cells allows them to communicate; and test how its disruption contributes to cancer invasion.

上皮细胞作为物理上连贯的集体群体迁移，这是正常发育所必需的，并且随着癌症的进展变得侵袭和扩散而中断。集体迁移需要沟通，这样单个细胞的行为才能得到适当的协调。在这个项目中，我们研究了物理力在细胞之间的传递如何使它们能够交流；并测试它的破坏是如何导致癌症入侵的。