A mechanotransduction apparatus to coordinate epithelial collective cell migration.
A mechanotransduction apparatus to coordinate epithelial collective cell migration.
批准号:
nhmrc : 1123816
负责人:
Prof Alpha Yap
金额:
$67.95万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2020-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Epithelial cells migrate as physically coherent collective groups, which is necessary for normal development and is disrupted as cancers progress to become invasive and spread. Collective migration requires communication so that the behaviour of individual cells is properly coordinated. In this project we investigate how the transmission of physical force between cells allows them to communicate; and test how its disruption contributes to cancer invasion.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Forces in Nature: Tissue mechanics and cell sociology
-
批准号:FL230100100
-
项目类别:Australian Laureate Fellowships
-
资助金额:$226.26万
-
财政年份:2024
-
负责人:Prof Alpha Yap
-
依托单位:
Keeping forces local for epithelial homeostasis
-
批准号:DP220103951
-
项目类别:Discovery Projects
-
资助金额:$41.1万
-
财政年份:2022
-
负责人:Prof Alpha Yap
-
依托单位:
RhoA signaling: the nanoscale mechanisms of mechanochemical regulation
-
批准号:DP190102871
-
项目类别:Discovery Projects
-
资助金额:$52.78万
-
财政年份:2019
-
负责人:Prof Alpha Yap
-
依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
-
批准号:nhmrc : 1140090
-
项目类别:Project Grants
-
资助金额:$73.78万
-
财政年份:2018
-
负责人:Prof Alpha Yap
-
依托单位:
Mechanobiology of epithelial homeostasis in health and disease
-
批准号:nhmrc : GNT1136592
-
项目类别:Research Fellowships
-
资助金额:$87.6万
-
财政年份:2018
-
负责人:Prof Alpha Yap
-
依托单位:
How caveolae condition tissue mechanics for an anti-tumor niche.
-
批准号:nhmrc : GNT1140090
-
项目类别:Project Grants
-
资助金额:$109.12万
-
财政年份:2018
-
负责人:Prof Alpha Yap
-
依托单位:
Mechanobiology of epithelial homeostasis in health and disease
-
批准号:nhmrc : 1136592
-
项目类别:Research Fellowships
-
资助金额:$59.23万
-
财政年份:2018
-
负责人:Prof Alpha Yap
-
依托单位:
Tissue tension homeostasis by junctional mechanosensing.
-
批准号:DP150101367
-
项目类别:Discovery Projects
-
资助金额:$31.22万
-
财政年份:2015
-
负责人:Prof Alpha Yap
-
依托单位:
Cadherin Biology in Morphogenesis and Disease
-
批准号:nhmrc : 1044041
-
项目类别:Research Fellowships
-
资助金额:$50.13万
-
财政年份:2013
-
负责人:Prof Alpha Yap
-
依托单位:
The Plasma membrane in health and disease
-
批准号:nhmrc : GNT1037320
-
项目类别:Programs
-
资助金额:$473.47万
-
财政年份:2013
-
负责人:Prof Alpha Yap
-
依托单位:
Program in Membrane Interface Biology
-
批准号:nhmrc : 1037320
-
项目类别:Program Grants
-
资助金额:$498.05万
-
财政年份:2013
-
负责人:Prof Alpha Yap
-
依托单位:
Mechanotransduction: a new paradigm for cadherin junction biology
-
批准号:DP120104667
-
项目类别:Discovery Projects
-
资助金额:$25.78万
-
财政年份:2012
-
负责人:Prof Alpha Yap
-
依托单位:
Cortactin: integrating cadherin signalling for junctional integrity
-
批准号:nhmrc : 1010489
-
项目类别:NHMRC Project Grants
-
资助金额:$39.6万
-
财政年份:2011
-
负责人:Prof Alpha Yap
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 631383
-
项目类别:NHMRC Research Fellowships
-
资助金额:$25.67万
-
财政年份:2010
-
负责人:Prof Alpha Yap
-
依托单位:
Myosin VI: a novel molecular apparatus for epithelial cohesion
-
批准号:nhmrc : 631377
-
项目类别:NHMRC Project Grants
-
资助金额:$40.35万
-
财政年份:2010
-
负责人:Prof Alpha Yap
-
依托单位:
Actin cytoskeleton regulation by E-cadherin and Src.
-
批准号:DP0988935
-
项目类别:Discovery Projects
-
资助金额:$20.8万
-
财政年份:2009
-
负责人:Prof Alpha Yap
-
依托单位:
Regulation of Myosin II by E-cadherin adhesion.
-
批准号:nhmrc : 511155
-
项目类别:NHMRC Project Grants
-
资助金额:$38.24万
-
财政年份:2008
-
负责人:Prof Alpha Yap
-
依托单位:
Preserving barriers: how cadherin signaling coordinates dynamic adhesion and tight junction assembly in epithelial cell.
-
批准号:nhmrc : 511156
-
项目类别:NHMRC Project Grants
-
资助金额:$37.2万
-
财政年份:2008
-
负责人:Prof Alpha Yap
-
依托单位:
Regulation of dynamic cell-cell adhesions by coordinated action of lipid kinases and phosphatases
-
批准号:nhmrc : 455824
-
项目类别:NHMRC Project Grants
-
资助金额:$35.31万
-
财政年份:2007
-
负责人:Prof Alpha Yap
-
依托单位:
Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins
-
批准号:DP0664395
-
项目类别:Discovery Projects
-
资助金额:$17.6万
-
财政年份:2006
-
负责人:Prof Alpha Yap
-
依托单位:
国内基金
海外基金
去泛素化酶USP21在纺锤体定向调控中的作用及分子机制
-
批准号:32000481
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:戚菲菲
-
依托单位:
特殊细胞壁结构调控质外体与共质体离子运输途径的分子基础和作用机制
-
批准号:31930024
-
项目类别:重点项目
-
资助金额:297.0万元
-
批准年份:2019
-
负责人:晁代印
-
依托单位:
CIA1 (Chloroplast Import Apparatus 1)调控拟南芥营养生长阶段转变的分子机理
-
批准号:31300997
-
项目类别:青年科学基金项目
-
资助金额:22.0万元
-
批准年份:2013
-
负责人:李小冬
-
依托单位: