Acquisition of a 500 MHz Triple-Resonance NMR Spectrometer

德克萨斯大学奥斯汀分校向美国国家科学基金会学术研究基础设施项目申请资金，用于购买一台500 MHz三共振核磁共振光谱仪。拟议的仪器将专门用于生物物理研究，具有最先进的核磁共振数据收集要求，并将大大加强八个主要用户的研究。拟议的文书将大大加强下列研究领域：RNA和蛋白质结构共价修饰DNA的抗生素的作用以及DNA与药物的相互作用生物活性多糖和多肽的结构代谢途径分析肌原纤维蛋白的结构RNA和DNA裂解剂的结构烃类化合物的酶降解基因工程肽的研究

The University of Texas at Austin requests funds from the Academic Research Infrastructure Program of the National Science Foundation for the purchase of a 500 MHz triple resonance NMR spectrometer. The proposed instrument will be dedicated to biophysical research with state-of-the-art NMR data collection requirements, and will greatly enhance the research of eight major users. The proposed instrument will significantly enhance the following areas of research: 1. RNA and protein structure 2. Effects of antibiotics that covalently modify DNA, and DNA-drug interactions 3. Structure of biologically active polysaccharides and peptides 4. Analysis of metabolic pathways 5. Structure of myofibrillar proteins 6. Structure of RNA and DNA cleavage agents 7. Enzymatic degradation of hydrocarbons 8. Studies of genetically engineered peptides