Transition-Metal-Catalysed Borane Dehydrocoupling and its Mechanistic Implications

寻找更有效的制备有用材料的方法是永恒的。因此，设计化学合成以限制废物是一个特别活跃的研究领域，其中一类反应接近低废物理想的顶峰：脱氢偶联。脱氢偶联反应是一种通过仅从混合物中除去氢气而在元素之间形成键的方法。虽然不是完全没有废物，但副产物H2很容易去除，可以用于其他目的，而且比产物分子轻得多。我们的初步工作是将这一概念应用于有机合成中广泛使用的二氮烷(4)的合成，使其具有高效率的催化合成。本研究旨在扩展这些结果，以扩大反应的范围，以不同的底物，利用新反应制备具有有趣性质的含硼聚合物，并从分子角度研究反应的机理。

The search for more efficient processes for the preparation of useful materials is perpetual.Thereby, the design of chemical syntheses that limit waste products is a particularly vibrant field of research, and one class of reactions is near the pinnacle of the low-waste ideal: dehydrocoupling. Dehydrocoupling reactions are a way to create bonds between elements by eliminating only hydrogen gas from the mixture. Although not completely waste-free, the by-product H2 is easily removed, can be used for other purposes and is much lighter than the product molecules. Our preliminary work on applying this concept to the synthesis of dibo-ranes(4), reagents widely used in organic synthesis, led to their catalytic synthesis with high efficiency. This proposal aims to expand these results in order to widen the scope of the reaction to different substrates, to use the new reaction to prepare boron-containing polymers with interesting properties, and to investigate the mechanism of the reaction from a molecular viewpoint.