Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides

该提案将解决我们质谱分析能力的差距，帮助我们理解细胞免疫反应，并研究免疫目标的化学多样性。这一提议在抗原呈递的基础免疫学、生物标志物发现以及传染病和癌症的新疫苗设计和自身免疫性疾病的疗法开发方面具有广泛的意义。除了这些关键的科学成果外，该项目还将促进在一个严重短缺的技能领域（质谱法）培训几名新人员，并促进跨学科技能（免疫学、生物化学、蛋白质组学）。

This proposal will address a gap in our mass spectrometry capabilities and aid in our understanding of the cellular immune response and investigate the chemical diversity of the targets of immunity. This proposal has broad implications in the basic immunology of antigen presentation, in biomarker discovery as well as in the design of new vaccines in infectious disease and cancer and the development of therapies for autoimmune diseases. In addition to these key scientific outcomes this project will also facilitate the training of several new personnel in a skill area for which there is a critical shortage (mass spectrometry) and promote cross-disciplinary skills (immunology, biochemistry, proteomics).