MRI: Acquisition of a CryoProbe-Enabled NMR Spectrometer for Enhanced Efficiency and Sensitivity in Chemical and Biological Research

该奖项由主要研究仪器和化学研究仪器项目联合支持。波士顿学院正在购买一台配备液氮冷却探针的500兆赫核磁共振（NMR）光谱仪，以支持Thusitha Jayasundera教授及其同事James Morken， Jianmin Gao， Jeffery Byers和Jia Niu的研究。该光谱仪允许在各种领域进行研究，例如那些加速具有重要经济意义的化学反应的领域，以及允许对化学和生物学相关物种进行研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。该探头使用氮冷却射频线圈，在室温下提供更大的灵敏度增强。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器是该机构化学和生物化学本科生和研究生以及来自邻近学院（主要是本科院校）的合作者的教学、研究和研究训练的一个组成部分。此外，该仪器是美国国家科学基金会资助的波士顿学院本科生研究经验（REU）计划和从纸到塑料（P2P）暑期计划以及其他外展计划（如女性参与科学技术（WST）计划）的一部分。这些项目主要由女性、第一代学生和/或在STEM学科中代表性不足的少数族裔组成。核磁共振光谱仪的奖励旨在加强各级的研究和教育。它尤其影响了非贵金属基催化剂的发展和合成分子的表征，以询问无法靶向药理学的生物分子，通常被称为“不可药物”。该仪器还用于开发新的合成方法，用于有机化学的应用，并用于鉴定由定制结构和序列制备的大分子。此外，它还可以表征金属催化中使用的物种，并用于理解微生物群落中的分子相互作用。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Boston College is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with liquid nitrogen cooled probe to support the research of Professor Thusitha Jayasundera and colleagues James Morken, Jianmin Gao, Jeffery Byers and Jia Niu. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of chemically and biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. The probe uses nitrogen-cooled radiofrequency coils that deliver a much greater sensitivity enhancement over room temperature. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution as well as collaborators from neighboring colleges including primarily undergraduate institutions. In addition, the instrument is part of activities involving the NSF funded Boston College Research Experience for Undergraduates (REU) program and the Paper to Plastics (P2P) summer program, as well as other outreach initiatives, such as the Women in Science and Technology (WST) program. These programs are largely composed of women, first generation students, and/or minorities that are under-represented in STEM disciplines.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts the development of non-noble metal-based catalysts and the characterization of synthesized molecules to interrogate biomolecules that cannot be targeted pharmacologically, commonly referred as "undruggable". The instrumentation is also used for developing new synthetic methods for applications in organic chemistry and for identifying macromolecules prepared with tailor-made structures and sequences. In addition, it allows the characterization of species used in metalloradical catalysis and for understanding molecular interactions in microbiome communities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.