Functional Dissection of the Bacterial Replisome

我们现在已经拥有了人类和许多其他生物体的完整基因序列，但我们对这些基因的蛋白质产物如何相互沟通来创造和生长细胞知之甚少。澳大利亚最近在可以用来解决这些问题的最先进的工具上投入了大量资金。该项目将涉及四个实验室的密切互动，以使用新的仪器来确定在制造DNA的生物机器中，大量蛋白质是如何相互作用的。这一过程在所有生物体中都以相似的方式发生，对生命是必不可少的。了解DNA是如何制造的，将有助于科学家开发新的抗菌药物，并学习如何实际使用模拟生物的分子机器。

We now have the complete sequences of genes in humans and many other organisms, but we know much less about how the protein products of the genes communicate with each other to create and grow cells. Australia has recently invested heavily in state-of-the-art instruments that can be used to tackle these problems. This project will involve close interaction of four laboratories to use new instruments to determine how a large assembly of proteins interact in a biological machine that makes DNA. This process occurs in similar ways in all organisms, and is essential for life. Understanding how DNA is made will help scientists to develop new antibacterial drugs, and learn how to make practical use of molecular machines that imitate biology.