Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network

在这篇文章中，我们试图通过在癌症相关的阳性和阴性免疫反应的多个重要点上结合免疫调节干预措施来开发有效的癌症免疫疗法。我们已经开发并评估了以下干预措施：1）诱导免疫原性癌细胞死亡的干预措施，2）在对化疗有抗性的癌症干细胞中表达的癌症抗原，3）刺激抗原呈递树突状细胞以用于抗癌T细胞活化的干预措施，4）活化抗癌T细胞的干预措施，5）逆转癌症诱导的免疫抑制的干预措施。使用小鼠肿瘤模型，我们评估了癌症免疫疗法，其中上述干预措施适当组合，特别是与免疫检查点阻断疗法。这些结果可能会导致开发更有效的癌症免疫疗法，通过评估在未来的临床试验。

In this sturdy, we have attempted to develop effective cancer immunotherapy by combining immune-regulating interventions on multiple important points in the cancer related positive and negative immune responses. We have developed and evaluated the following interventions; 1) interventions to induce immunogenic cancer cell death, 2) cancer antigens expressed in cancer stem cells which are resistant to chemotherapy, 3) interventions to stimulate antigen presenting dendritic cells for anti-cancer T-cell activation, 4) interventions to activate anti-cancer T-cells, 5) interventions to reverse cancer-induced immunosuppression. Using mouse tumor models, we have evaluated cancer immunotherapies in which the above interventions are appropriately combined, particularly with immune-checkpoint blockade therapies. These results may lead to development of more effective cancer immunotherapies through evaluation in the future clinical trials.