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An X-ray crystallographic investigation into co-receptors on T-lymphocytes

An X-ray crystallographic investigation into co-receptors on T-lymphocytes
T 淋巴细胞共受体的 X 射线晶体学研究
批准号:
DP0346007
负责人:
Prof Jamie Rossjohn
金额:
$33.21万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-01-01 至 2005-12-31

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中文摘要
翻译
T淋巴细胞是免疫系统不可或缺的细胞成分。胸腺中T细胞选择的正常过程和成熟T细胞对外来抗原的应答能力由受体识别和共受体介导的事件控制。 共受体包括参与粘附、共连接和信号转导的广泛的结构上不同的蛋白质。该提案旨在使用X射线晶体学作为主要研究工具来研究位于T淋巴细胞上的共受体。 这项工作将获得对辅助受体功能的基本见解。
英文摘要
T lymphocytes are an indispensable cellular component of the immune system. The normal process of T cell selection in the thymus, and the ability of mature T cells to respond to foreign antigens are governed by receptor recognition and co-receptor mediated events. The co-receptors encompass a wide spectrum of structurally diverse proteins that are involved in adhesion, co-ligation and signal transduction. This proposal aims to investigate, using X-ray crystallography as the primary research tool, co- receptors located on T-lymphocytes. This work will gain fundamental insights into co-receptor function.
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海外基金