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Roles of adipocytokines in colorectal carcinogenesis and identification of preventive food factors

Roles of adipocytokines in colorectal carcinogenesis and identification of preventive food factors
脂肪细胞因子在结直肠癌发生中的作用及预防性食物因素的鉴定
批准号:
20580129
负责人:
MURAKAMI Akira
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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相关文献

中文摘要
翻译
目前,肥胖在许多发达国家呈趋势,越来越多的证据表明肥胖与结直肠癌的发生有关。在本研究中,我试图找出在肥胖和结直肠癌过程中伴随调节的内源性因素。瘦素被认为是在结肠化学癌变过程中增加的重要激素。此外,柑橘褐皮素被认为是一种有前景的植物化学物质,能够适当调节瘦素水平,防止小鼠结肠肿瘤的发生。
英文摘要
At present, obesity is trending in many developed countries, and there is increasing evidence that obesity is associated with colorectal carcinogenesis. In the present study, I attempted to identify endogenous factors which are concomitantly regulated in the processes of obesity and colorectal cancer. Leptin was suggested to be important hormone that increased during chemical carcinogenesis in the colon. In addition, citrus nobiletin was identified to be a promising phytochemical that is capable of regulating leptin levels appropriately and preventing colon tumorigenesis in mice.
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会议论文
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Dietary flavonoids suppress azoxymethane-induced colinic preneoplastic lesions in male C57BL/KsJ-db/db mice
膳食黄酮类化合物抑制氧化偶氮甲烷诱导的雄性 C57BL/KsJ-db/db 小鼠结肠肿瘤前病变
DOI: --
发表时间: 2010
期刊: Chemico-Biological Interactions 183(2)
影响因子: --
作者: [Miyamoto S, Yasui Y, Ohigashi H, Tanaka T, Murakami A]
通讯作者: Murakami A
DOI: 10.1016/j.cbi.2009.11.002
发表时间: 2010-01-27
期刊: CHEMICO-BIOLOGICAL INTERACTIONS
影响因子: 5.1
作者: [Miyamoto, Shingo, Yasui, Yumiko, Murakami, Akira]
通讯作者: Murakami, Akira
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [松田寛子, 五味亮太, 平井静, 江頭祐嘉合, 村上明]
通讯作者: 村上明
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    • 负责人:
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