'The lung- gut network'contributes to development of chronic obstructive pulmonary disease (COPD).

在烟雾暴露的动物中，摄食量和体重增加比不吸烟的对照组少，而血浆酰基胃促生长素水平升高。此外，还发现盲肠细菌区系发生了变化，短链脂肪酸减少。补充无纤维饲料可显著抑制体重增加、肠道环境恶化和血清抗氧化活性降低。结果表明，无纤维饮食间歇喂养可加速弹性酶诱导的大鼠肺气肿，而摄食量并未减少，提示香烟烟雾引起的肠道环境恶化可能导致营养耗竭和全身炎症，进而导致肺气肿的发生。综上所述，我们证明了肺肠网络的存在，它可能与慢性阻塞性肺疾病的发生发展有关。

In smoke exposed animals, food intake and body weight gain were less than those in non-smoking controls while plasma acyl-ghrelin levels were elevated. In addition, the change in bacterial flora and decrease in short chain fatty acids in cecum were found. Supplementation of fiber-free diet resulted in remarkable suppression of body weight gain, deterioration of gut environment and the reduction of serum antioxidant activity. It was shown that discontinuous feeding with fiber-free diet accelerated elastase- induced emphysema in smoke exposed rats, while amount of food intake did not decreased.These data suggest that deterioration of gut environment by cigarette smoke may contribute to nutritional depletion and systemic inflammation, which in turn may develop the pulmonary emphysema. In conclusion, we have demonstrated an existence of lung-gut network which may be associated with the development of chronic obstructive lung disease.