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The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy

The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy
视网膜神经变性对糖尿病视网膜微血管病变发生发展的影响
批准号:
20592043
负责人:
NAKAMURA Makoto
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
翻译
研究糖尿病视网膜病变中神经退行性变与微血管病变的关系。实验性糖尿病大鼠视网膜显示视网膜神经元加速凋亡,这与胶质水通道蛋白表达改变相一致。这些发现与糖尿病引起的神经胶质细胞向神经元的水分运输障碍和血管增殖性改变有关。对糖尿病乳头状病变患者的光学相干断层扫描分析表明,视神经头的胶质组织可能是第三血-视网膜屏障。
英文摘要
The association of neurodegeneration with microangiopathy in diabetic retinopathy was investigated. Experimental diabetic rat retinas showed accelerated apoptosis of retinal neurons that coincided with altered expression of glial aquaporin water channels. These findings implicated in the impaired water transport from glia to neurons and vasoproliferative changes induced by diabetes. Optical coherent tomographic analysis of patients with diabetic papillopathy indicated that glial tissues of the optic nerve head may act as the third blood-retinal barrier.
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DOI: 10.2353/ajpath.2008.080466
发表时间: 2008-11-01
期刊: AMERICAN JOURNAL OF PATHOLOGY
影响因子: 6
作者: [Murakami, Yusuke, Ikeda, Yasuhiro, Sueishi, Katsuo]
通讯作者: Sueishi, Katsuo
DOI: 10.1016/j.exer.2009.09.003
发表时间: 2010-01-01
期刊: EXPERIMENTAL EYE RESEARCH
影响因子: 3.4
作者: [Fukuda, Masahide, Nakanishi, Yoriko, Nakamura, Makoto]
通讯作者: Nakamura, Makoto
The role of aquaporin in glaucomatous optic neuropathy.
水通道蛋白在青光眼视神经病变中的作用。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [西村忠己,山下哲範,岡安唯, 細井裕司, Makoto Nakamura]
通讯作者: Makoto Nakamura
The role of aquaporin in glaucomatous optic neuropathy
水通道蛋白在青光眼性视神经病变中的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yamanari M, Ishii K, Miura M, Oshika T, Yasuno Y, Makoto Nakamura]
通讯作者: Makoto Nakamura
共 16 条
    Burst-mode Receiver with Analog and Digital Conrols for Optical Packet Networks
    • 批准号:
      17K06381
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2017
    • 负责人:
      NAKAMURA Makoto
    • 依托单位:
    Burst-mode Receiver with High-speed Digital Conrols for Optical Packet Networks
    • 批准号:
      26420304
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2014
    • 负责人:
      NAKAMURA Makoto
    • 依托单位:
    Role of aquaporin in retinal and optic nerve degenerative disorders
    • 批准号:
      26462661
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2014
    • 负责人:
      NAKAMURA Makoto
    • 依托单位:
    Quality Estimation Support Models of Fresh Fish in the Distribution Using Soft Computing
    • 批准号:
      25330302
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      NAKAMURA Makoto
    • 依托单位:
    海外基金