PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
批准号:
2590282
负责人:
M S LEWIS
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
CD40 molecule DNA repair HIV envelope protein gp120 T cell receptor analytical ultracentrifugation biophysics cell cycle proteins chemical structure function human immunodeficiency virus 1 human tissue integrase intermolecular interaction macromolecule mathematical model model design /development thermodynamics transcription factor
中文摘要
这个项目的目的是研究一个广泛的物理性质
各种生物大分子,并将这些特性与
大分子的结构和功能。 重点是
这些大分子之间相互作用的热力学及其
分子大小和形状。 分析超浓缩和
数学建模是主要的研究技术。 之间
所研究的相关系统是多功能的,
chromagranins A和B,细胞周期调节蛋白p53,T细胞
受体、DNA修复蛋白、HIV-1整合酶和CD 4结合
HIV gp 120的C4结构域。
英文摘要
The purpose of this project is to study the physical properties of a wide
variety of biological macromolecules and correlate these properties to
the structure and function of the macromolecules. The emphasis is on the
thermodynamics of the interactions of these macromolecules and on their
molecular sizes and shapes. Analytical ultracentrifugation and
mathematical modeling are the principal research techniques used. Among
the associated systems studied have been the multifunctional
chromagranins A and B, the cell cycle regulatory protein p53, T-cell
receptors, DNA repair proteins, HIV-1 integrase, and CD4 binding to the
C4 domain of HIV gp120.
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BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3916170
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3937297
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3789382
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3896158
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3896167
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:6163162
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:5204045
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3937284
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3959941
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3874157
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:4705611
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3852920
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3959923
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3767417
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3874165
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3916181
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3978305
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY
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批准号:3978284
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:5204051
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
PHYSICAL CHEMISTRY OF BIOLOGICAL MACROMOLECULES
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批准号:3767423
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:M S LEWIS
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依托单位:
海外基金