STUDY OF NORMAL HUMAN VARIABILITY AND CROSS CULTURAL AGING

该项目是一项持续的合作努力， 世卫组织和其他国家和国际实验室协调 收集、评估和解释正常遗传学 标记，以研究遗传的跨文化模式 和外在因素，因为它们与正常老化和 迟发性疾病。具体而言，本 研究内容有：A）研究DNA小卫星的分布， 皮纹学、侧向优势和其他遗传变量 BLSA参与者和其他对照样本以及患者 晚发性疾病B）研究水稻的遗传分离 这些标志物在迟发性疾病的家庭中， 老年痴呆症、乳腺癌、肌萎缩性侧索硬化症和其他疾病， 建立遗传联系，并最终确定 导致这些疾病的因素和C）研究交叉 文化模式的遗传和非遗传因素， 来更好地理解正常衰老的过程。

This project represents an ongoing collaborative effort, involving WHO and other national and international laboratories to coordinate the collection, evaluation and interpretation of normal genetic markers in order to study the cross-cultural patterns of genetic and extraneous factors as they relate to normative aging and to diseases with late onset. Specifically, the objectives of this study are: A) To study the distribution of DNA-minisatellites, dermatoglyphics, lateral dominance and other genetic variables in BLSA participants and other control samples, as well as in patients with late onset diseases. B) To study the genetic segregation of these markers in families with late onset diseases, such as Alzheimer's disease, breast cancer, ALS and others, in an effort to establish genetic linkages and eventual identification of the factors responsible for these diseases and C) To study the cross cultural patterns of genetic and non genetic factors in an effort to better understand the process of normative aging.