IN VIVO 17O NMR STUDIES OF CEREBRAL OXYGEN CONSUMPTION AND BLOOD FLOW

该项目涉及开发新的非侵入性方法 成像大脑中的耗氧量和血流量。这些新的 这些方法结合了磁共振光谱学的优点， 它可以从不同的代谢物或“示踪剂”中分离出信号 大脑，以及磁共振成像，它可以定位来自 代谢物和示踪剂到大脑明确定义的区域。如果170- 标签水，这是氧化新陈代谢的最终产物 大脑。如果血液流动也被成像，170- 标记的水信号可以用来计算氧气的速率 消费。在过去的一年里，我们已经证明了19F核磁共振技术可以 用于以0.4cc的空间分辨率成像脑血流， 这与正电子发射计算机断层扫描的空间演化大致相同。我们还有 表明~(19)F-核磁共振方法可以与170个核磁共振方法相结合 同时成像脑血流量和氧耗量。170 核磁共振方法与150PET方法非常相似，用于脑成像 耗氧量和血流量。在目前，空间 170方法的分辨率为0.8cc，不如 空间分辨率为150PET(约0.5cc)。然而，170 核磁共振方法有两个重要的优点：第一，170标记的化合物 是无放射性和无毒的，第二，对170 光谱数据比150PET的解释简单得多 数据。

This project involves the development of new non-invasive approaches for imaging oxygen consumption and blood flow in the brain. These new approaches combine the advantages of magnetic resonance spectroscopy, which can separate signals from different metabolites or "tracers" in the brain, and magnetic resonance imaging, which can localize signals from metabolites and tracers to well-defined regions of the brain. If 170- labeled water, which is the end product of oxidative metabolism in the brain. If the blood flow is also imaged, the rate of increase in the 170- labelled water signal can be used to calculate the rate of oxygen consumption. In the last year we have shown that 19F NMR techniques can be used to image cerebral blood flow with a spatial resolution of 0.4 cc, which is approximately the same spatial evolution as PET. We have also shown that 19F NMR approaches can be combined with 170 NMR approaches to image simultaneously cerebral blood flow and oxygen consumption. The 170 NMR approach is very similar to the 150 PET approach for imaging cerebral oxygen consumption and blood flow. At the present time, the spatial resolution of the 170 approach is 0.8 cc, which is not as good as the spatial resolution of 150 PET (approximately 0.5 cc). However, the 170 NMR approach has two important advantages: first, 170-labeled compounds are non-radioactive and non-toxic, and second, the interpretation of 170 spectroscopic data is much simpler than the interpretation of 150 PET data.