STUDY OF NORMAL HUMAN VARIABILITY AND CROSS CULTURAL AGING

该项目是一项持续的合作努力，世卫组织和 其他国家和国际实验室协调 正常遗传标记的收集、评价和解释 为了研究遗传和外源的跨文化模式 与正常老龄化和起病晚的疾病有关的因素， 包括骨质流失、阿尔茨海默病、乳腺癌、肌营养不良 侧索硬化症和帕金森氏痴呆症。具体地说， 本研究的目的是：a)研究中国留学生的跨文化模式 遗传和非遗传因素，努力更好地了解 规范老化的过程。B)研究这些基因的遗传分离 晚发性疾病家族中的标志物，如阿尔茨海默病 乳腺癌、肌萎缩侧索硬化症和其他疾病，努力建立基因联系 并最终确定导致这些疾病的因素。 C)研究皮纹的分布、侧向优势和 BLSA参与者和其他对照样本中的其他遗传变量，如 晚发性疾病的患者也是如此。

This project represents an ongoing collaborative effort, involving WHO and other national and international laboratories to coordinate the collection, evaluation and interpretation of normal genetic markers in order to study the cross-cultural patterns of genetic and extraneous factors as they relate to normative aging and to diseases with late onset, including bone loss, Alzheimer's disease, breast cancer, amyotrophic lateral sclerosis, and Parkinsonism dementia. Specifically, the objectives of this study are: A) To study the cross cultural patterns of genetic and non-genetic factors in an effort to better understand the process of normative aging. B) To study the genetic segregation of these markers in families with late onset diseases, such as Alzheimer's disease, breast cancer, ALS and others, in an effort to establish genetic linkages and eventual identification of the factors responsible for these diseases. C) To study the distribution of dermatoglyphics, lateral dominance and other genetic variables in BLSA participants and other control samples, as well as in patients with late onset diseases.