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MOLECULAR DEFINITION OF FILARIAL ANTIGENS

MOLECULAR DEFINITION OF FILARIAL ANTIGENS
丝虫抗原的分子定义
批准号：
3768813
负责人：
T B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768813
关键词：
Filarioidae Wuchereria filariasis genome helminthic antigen immediate hypersensitivity microorganism genetics microorganism immunology molecular biology nucleic acid probes recombinant DNA recombinant proteins species difference

项目摘要

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中文摘要
翻译
该项目的目标是定义和生成丝虫 在诱导寄生虫特异性免疫反应中起重要作用的蛋白质 并在分子水平上理解这些差异 在相关的丝虫物种中。重组抗原和探针已经被 确定：a)编码具有免疫活性和潜在保护性的 Bancrofti；b)的分子可以区分相关的丝虫病 物种；c)鉴定班氏假丝酵母基因组的重复片段 或LOA LOA；d)可能具有潜在的诊断重要性和e) 诱导淋巴丝虫病患者的即刻超敏型反应 综合症。
英文摘要
The objectives of this project are to define and generate filarial proteins that are important in inducing parasite-specific immune responses in the human host and to understand, at a molecular level, the differences among related filarial species. Recombinant antigens and probes have been identified that: a) encode immunoreactive and potentially protective molecules of W. bancrofti; b) can distinguish among related filarial species; c) identify repeated segments of W. bancrofti genome, O. volvulus or that of Loa loa; d) may be of potential diagnostic importance and e) induce immediate hypersensitivity type responses in lymphatic filarial syndromes.
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MOLECULAR DEFINITION OF FILARIAL ANTIGENS
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
IMMUNOREGULATION AND IMMUNE RECOGNITION IN FILARIASIS AND NON-FILARIAL DISEASES
MOLECULAR DEFINITION OF FILARIAL ANTIGENS