BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

在男性和女性中， 妇女 骨转换标志物的年龄和性别相关差异是 在阐明正常衰老过程中骨生理学变化方面具有重要意义， 疾病 这些标志物中的2种，骨钙素（OC）和 研究了尿吡啶酚（PYD）与年龄、性别及相互关系。 来自巴尔的摩纵向研究的164名正常男性和101名正常女性 的老化。 男性和女性的PYD均随年龄的增长而线性增加（p <0.05）。 0.0001），所有年龄段女性的平均PYD均较高。 的关系 血清OC随年龄增长呈双相性，年轻男性和女性的水平 而老年男性和女性没有显着下降， 与年龄的相关性 尿PYD水平与血清OC水平相关 在老年男性和老年女性中均如此，但在两个年轻组中均未如此。 的 在整个年龄范围内的关系是显着的会计后， 年龄的影响，通过多元回归。 男性和女性的尿PYD均随年龄增长而增加，女性 在整个年龄段都有更高的水平。 PYD与OC的关系 无论男女，不受年龄的影响， 这两个骨转换的标志物。 缺乏联系， 年轻的组可能表明骨生长的优先过程， 最年轻的成年人

Age-related changes in bone mass have been demonstrated in both men and women. Age and sex related differences in markers of bone turnover are important in elucidating changes in bone physiology in normal aging and disease. The relationship of 2 of these markers, Osteocalcin (OC) and urine pyridinoline (PYD), to age and sex and to each other was studied in 164 normal men and 101 normal women from the Baltimore Longitudinal Study of Aging. PYD increased linearly with age in both men and women (p < .0001), with mean PYD higher in females at all ages. The relationship of serum OC with age was biphasic, with levels in young men and women decreasing significantly while older men and women showed no significant correlation with age. Urine PYD levels were correlated to serum OC levels in both old men and old women but not in either young group. The relationship across the entire age range was significant after accounting for the effect of age by multiple regression. Urinary PYD increases with age in both men and women, with women having higher levels across the entire age span. The relationship of PYD to OC in both men and women, independent of any effects of age, indicates coupling of these two markers of bone turnover. the lack of an association in the young groups may indicate a preferential process of bone accretion in the youngest adults.