STUDY OF NORMAL HUMAN VARIABILITY AND CROSS CULTURAL AGING

该项目代表着持续的合作努力，包括 世卫组织和其他国家和国际实验室 协调收集、评价和解释正常 遗传标记，为了研究人类的跨文化模式 与正常衰老有关的遗传和外在因素 以及发病较晚的疾病。具体地说， 本研究是：a)为了研究DNA小卫星的分布， 皮纹学、侧向优势度和其他遗传变量 BLSA参与者和其他对照样本，以及 起病较晚的患者。B)研究基因 这些标记物在晚发性疾病家庭中的分离， 如阿尔茨海默氏症、乳腺癌、肌萎缩侧索硬化症等 努力建立遗传联系并最终确定 这些疾病的致病因素及C)研究 遗传性因素和非遗传性因素的跨文化模式 努力更好地理解规范老龄化的过程。

This project represents an ongoing collaborative effort, involving WHO and other national and international laboratories to coordinate the collection, evaluation and interpretation of normal genetic markers, in order to, study the cross-cultural patterns of genetic and extraneous factors as they relate to normative aging and to diseases with late onset. Specifically, the objectives of this study are: A) To study the distribution of DNA minisatellites, dermatoglyphics, lateral dominance and other genetic variables in BLSA participants and other control samples, as well as in patients with late onset diseases. B) To study the genetic segregation of these markers in families with late onset diseases, such as Alzheimer's disease, breast cancer, ALS and others, in an effort to establish genetic linkages and eventual identification of the factors responsible for these diseases and C) To study the cross cultural patterns of genetic and non genetic factors in an effort to better understand the process of normative aging.