LOBELINE AND NICOTINE--SUBJECTIVE, PHYSIOLOGIC AND KINETIC EFFECTS

洛贝林用于多种非处方药的吸烟辅助药物 停药，但在科学研究中从未记录过 有效地帮助戒烟。然而，实验数据表明， 它在替代配方和/或呈现中可能更有效 在更高的剂量水平下。尽管洛贝林被广泛使用，但仍有 关于其动力学或对人体的特定剂量相关效应的数据很少 主观和生理反应及其对卷烟的影响 抽烟。本研究的主要目的是确定 洛贝林5分钟静脉给药的安全性 剂量不超过8毫克。本研究还比较了两种方法的效果 洛贝林、安慰剂和尼古丁静脉注射的前处理 关于生理效应、主观效应和动力学。此外, 这些药物对吸烟行为的影响也是 已评估。我们最近完成了这项研究，目前正在 在写报告。四名受试者完成了全部剂量范围的 洛贝林和尼古丁对两种心血管疾病均无不良影响 测量(心电图、血压、心率)或其他主观影响。 这些结果表明洛贝林即使5分钟给药也是安全的。 静脉注射剂量最高可达8毫克。对主观方面的考察 效果数据表明，注射的剂量不会产生任何 效果类似于标准的滥用药物。初步结果也 表明洛贝林和尼古丁的剂量使用 本研究中的注射程序没有显示出任何减少 吸烟行为。在这个时候，血浆样本还没有 进行了分析，因此没有动力学数据。

Lobeline is used in a variety of over-the-counter aids for smoking cessation but it has never been documented in scientific studies to be efficacious as an aid to cessation. Experimental data, however, suggests that it may be more effective in alternate formulations and/or presented at higher dose levels. Despite the wide spread use of lobeline there are little data on its kinetics or specific dose-related effects on human subjective and physiologic responses, and on its effects on cigarette smoking. The major purpose of the present study was to determine the safety of lobeline given intravenously over a period of 5 minutes in doses up to 8 mg. The present study also compared the effects of pretreatment of intravenously administered lobeline, placebo and nicotine on physiologic effects, subjective effects and kinetics. In addition, the effects of these drugs on cigarette smoking behavior was also evaluated. We have recently completed this study and are currently writing up the report. Four subjects completed the full dose-range of lobeline and nicotine with no adverse effects on either cardiovascular measures (ECG, blood pressure, heart rate) or other subjective effects. These results suggest that lobeline is safe even when given as a 5 min intravenous injection up to doses of 8 mg. Inspection of the subjective effects data suggest that doses administered were not producing any effects similar to standard drugs of abuse. Preliminary results also indicate that the doses of lobeline and nicotine administered using the injection procedure in the present study did not show any decreases on cigarette smoking behavior. At this time, plasma samples have yet to be analyzed so there are no kinetic data.