MITRAL VALVE ALTERATIONS IN HYPERTROPHIC CARDIOMYOPATHY

为了评估二尖瓣本身可能涉及 肥厚型心肌病（HC），我们研究了94例二尖瓣 HC组45例，正常对照组45例。 的面积 与对照组相比，HC患者的二尖瓣瓣叶增加 (12.9-/+ 3.7对比8.7 +/- 2.0 cm 2; p < 0.0001）。这一增长是由于 主要是前叶长度增加（HC为2.2 +/- 0.5 vs. 1.8对照组为+/- 0.3 cm; p < 0.001），因为周长不 两组之间的差异。 二尖瓣瓣叶面积增加（等于 或小于12.0 cm 2）。 在这55个中的12个中， 瓣膜前后叶均增大， 43个瓣膜的前壁或后壁不对称或节段性扩大， 瓣叶（36例）或后叶中部（7例 患者）。 9例患者患有先天性二尖瓣畸形 一个或两个乳头肌直接插入的装置 二尖瓣前叶

To assess the possibility that the mitral valve itself may be involved in hypertrophic cardiomyopathy (HC), we studied mitral valves from 94 patients with HC and 45 in normal control subjects. The area of the mitral leaflets were increased in patients with HC compared to controls (12.9 -/+ 3.7 vs. 8.7 +/- 2.0 cm2; p < 0.0001). This increase was due primarily to an increase in anterior leaflet length (2.2 +/- 0.5 for HC vs. 1.8 +/- 0.3 cm for controls; p < 0.001), since circumference did not differ between the 2 groups. Mitral leaflet area was increased (equal to or less than 12.0 cm2) in 55 (58%) of the 94 valves. In 12 of these 55 valves both the anterior and posterior leaflets were enlarged; the other 43 valves had asymmetric or segmental enlargement of either the anterior leaflet (36 patients) or the midportion of posterior leaflet (7 patients). Nine patients had a congenital malformation of the mitral apparatus in which one or both papillary muscles inserted directly into anterior mitral leaflet.