PHYSIOLOGICAL ANALYSIS OF VOLUNTARY MOVEMENT

对自主活动的研究主要集中在小脑的作用上。一 问题是小脑对协调的贡献。这个 结果似乎表明，小脑对于 多关节运动的协调。小脑的作用不仅仅是 随着移动速度的提高，这一点很重要。第二个问题是角色 小脑在运动学习中的作用。在运动技能学习任务中， 已经证明，有小脑功能障碍的患者可以 学习，但学习是有限的，当运动的速度是 更大。我们还研究了小脑对 条件反射。有小脑缺陷的患者有明显的障碍 条件性眨眼的习得。5-羟色胺治疗非小细胞肺癌的临床研究 当一个可能的嗜酸性粒细胞增多症病例时，小脑性共济失调停止 出现肌痛综合征。 用0-15标记水作为正电子脑血流量的标志物 发射断层扫描(PET)研究，我们一直致力于方法 通过以下方式改善代谢变化区域的解剖相关性 将PET图像叠加到MRI图像上。大脑的各个区域 通过随意运动、手部振动和前夜运动来激活 已经被识别和量化。一项专门的研究致力于 顶叶皮质在触觉控制中的作用。研究包括 小脑在运动学习中的作用分析 自定步速运动中的辅助运动区。 运动相关皮层电位的研究主要集中在 识别用于产生不同分量的偶极子 事件相关测量技术的发展 脑电去同步化。研究已经在患者身上完成 肌张力障碍表现为某些成分的幅度降低。 医学系生物力学实验室的研究 康复医学一直专注于平衡和步态的控制。 一项关于自闭症患者步态的研究已经完成，研究表明没有 系统性异常。小脑患者也有类似的项目 失调症正在恶化。其他关于平衡的研究正在进行中。 有小脑缺陷的患者。

Studies of voluntary movement focused on the role of the cerebellum. One issue was the contribution of the cerebellum to coordination. The results seem to indicate that the cerebellum is critical for the coordination of multijoint movement. The role of the cerebellum is more important as the speed of movement increases. A second issue is the role of the cerebellum in motor learning. In tasks of motor skill learning, it has been demonstrated that patients with cerebellar disturbances can learn, but the learning is limited when the speed of the movement is greater. We have also studied the contribution of the cerebellum to conditioning. Patients with cerebellar deficits have a marked disorder of acquisition of conditioned eyeblink. A therapeutic trial of 5-HTP for cerebellar ataxia was stopped when a probable case of eosinophilia myalgia syndrome occurred. Using 0-15 labelled water as a marker for cerebral blood flow in positron emission tomography ( PET) studies, we have been working on methods for improved anatomic correlation of regions of metabolic change by superimposing the PET image onto an MRI image. Regions of the brain activated with voluntary movement, vibration of the hand and eve movement have been identified and quantified. A special study was devoted to the role of parietal cortex in the control of reaching. Studies include analysis of the role of the cerebellum in motor learning and the supplementary motor area in self-paced movement. Studies of movement-related cortical potentials have focused on identifying dipoles for the generation of the different components and the development of techniques for measuring event related desynchonization of the EEG. Studies have been completed in patients with dystonia that show reduction in amplitude of some components. Studies in the Biomechanics Laboratory of the Department of Rehabilitation Medicine have focused on the control of balance and gait. A study has been completed of gait in patients with autism that shows no systematic abnormality. A similar project in patients with cerebellar disorders is in progress. Other studies are being done of balance in patients with cerebellar deficits.