BIOPHYSICAL INSTRUMENTATION AND METHODOLOGY

该项目旨在开发新的仪器和方法， 改进现有的仪器和技术， 生物大分子及其相互作用的研究。 分析 超浓缩技术及其辅助技术和数据处理方法 使用适合于这些技术的数学建模的分析是 感兴趣的主要领域。 数学建模在工程问题中的应用研究 超临界分析仍在继续。 这些应用程序 研究报告见项目报告10184-06。 重大进展 在数据采集系统的开发。 两个新的数据 已经开发了用于分析超浓缩物的采集系统。 Macintosh II模拟数字采集系统也已被 完成和使用Macintosh的直接数字采集系统， 几乎完成了。 进行实验和分析数据的新方法 已经制定，这方面的工作仍在继续。

The project is designed to develop new instrumentation and methods and to improve existing instrumentation and techniques for the characterization of biological macromolecules and for study of their interactions.. Analytical ultracentrifugation, the techniques ancillary to it, and methods of data analysis using mathematical modeling appropriate for these techniques are the major areas of interest. Studies on the application of mathematical modeling to problems of ultracentrifugal analysis have continued. The applications of these studies are described in the project report 10184-06. Major progress has been made in the development of data acquisition systems. Two new data acquisition systems for the analytical ultracentrifuge have been developed. The Macintosh II analog-to-digital acquisition system has also been completed and a direct digital acquisition system using the Macintosh is nearly completed. New methods of performing experiments and analyzing data have been developed and work is continuing in this area.